Background Nuclear magnetic resonance (NMR) imaging and spectroscopy have been applied
to assess skeletal muscle oxidative metabolism. Therefore, in-vivo NMR may enable the …

Cold agglutinin disease is a difficult-to-treat autoimmune hemolytic anemia in which
immunoglobulin M antibodies bind to erythrocytes and fix complement, resulting in predominantly …

ASN100 is a novel antibody combination of two fully human IgG1(κ) monoclonal antibodies (MAbs),
ASN-1 and ASN-2, which neutralize six Staphylococcus aureus cytotoxins, alpha-…

Aberrant activation of the classical complement pathway is the common underlying
pathophysiology of orphan diseases such as bullous pemphigoid, antibody‐mediated rejection of …

Granulocyte colony-stimulating factor (G-CSF) stimulates the bone marrow to produce
granulocytes and stem cells and is widely used to accelerate neutrophil recovery after …

There are no dose-finding trials available for rituximab that could guide dosing in non-malignant
diseases. We hypothesized that currently used doses (≥375 mg/m 2 ) exceed several …

Aims The local pulmonary inflammatory response has a different temporal and qualitative
profile compared with the systemic inflammatory response. Although glucocorticoids …

Intravenous infusions of different iron formulations are recognized as a cause of hypophosphatemia.
Chronic hypophosphatemia can alter bone metabolism and bone material structure. …

Background Complement may play a key role in antibody-mediated rejection. A promising
therapeutic approach may be classical pathway (CP) inhibition at the level of early component …

Background and Aims With rising rates of inflammatory bowel diseases [IBD] in older adults,
management of comorbidities such as osteoporosis is becoming increasingly important. Hip …