We report here the discovery of a unique and novel angiotensin binding site and peptide
system based upon the C-terminal 3–8 hexapeptide fragment of angiotensin II (NH 3 + -Val-Tyr-…

A unique angiotensin binding site specific for the hexapeptide, AII(3–8), has been identified
in guinea pig hippocampus. This binding site, which is present in the pyramidal cell layer of …

Our laboratory has reported previously that a unique binding site specific for the hexapeptide
angiotensin (A)II(3-8), now referred to as AIV, is present in a number of tissues including …

AT 4 receptor: Specificity and distribution. The AT 4 receptor specifically binds Angiotensin (Ang)
IV and is distinct from the AT 1 and AT 2 receptors which bind Ang II and Ang III. The AT …

Data are presented describing a new angiotensin binding site in rabbit and guinea pig heart,
distinct from AT1 and AT2, that demonstrates high specificity and affinity for the …

A new class of angiotensin receptors has recently been identified that exhibits both high
specificity and affinity for the hexapeptide (3–8) fragment of angiotensin II, angiotensin IV (AngIV)…

Divalinal-Ang IV [Vψ(CH 2 -NH 2 )YVψ(CH 2 -NH 2 )HPF] is being employed increasingly
as a specific AT 4 antagonist. This use, which necessitates a comprehensive physiological …

This study demonstrates the existence of a previously unrecognized class of angiotensin
binding sites on vascular smooth muscle that exhibit high affinity and specificity for the …

Recent evidence from our laboratory suggests that angiotensin II (AH) is synthesized, stored
within cells in the paraventricular nucleus (PVN) of the hypothalamus, and upon appropriate …

The angiotensin IV receptor (AT 4 ) receptor is widely distributed in both species and tissues.
This broad distribution appears to be reflected in an equally diverse repertoire of …