Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians

…, JJM Lee, NR Lee, Y Li, JJ Liu, W Lu, J Nakamura… - Nature …, 2012 - nature.com
We conducted a three-stage genetic study to identify susceptibility loci for type 2 diabetes (T2D)
in east Asian populations. We followed our stage 1 meta-analysis of eight T2D genome-…

Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population

…, M Miyagishi, N Nakashima, H Nawata, J Nakamura… - Diabetes, 2009 - Am Diabetes Assoc
OBJECTIVE To identify novel type 2 diabetes gene variants and confirm previously identified
ones, a three-staged genome-wide association study was performed in the Japanese …

Transplantation of bone marrow–derived mesenchymal stem cells improves diabetic polyneuropathy in rats

…, M Kozakae, M Kondo, Y Yasuda, N Nakamura… - Diabetes, 2008 - Am Diabetes Assoc
OBJECTIVE—Mesenchymal stem cells (MSCs) have been reported to secrete various
cytokines that exhibit angiogenic and neurosupportive effects. This study was conducted to …

A protein kinase C-beta-selective inhibitor ameliorates neural dysfunction in streptozotocin-induced diabetic rats.

J Nakamura, K Kato, Y Hamada, M Nakayama… - Diabetes, 1999 - Am Diabetes Assoc
Increased protein kinase C (PKC) activity has been implicated in the pathogenesis of diabetic
retinopathy and nephropathy. However, the role of PKC in diabetic neuropathy remains …

Effects of irradiation of an erbium: YAG laser on root surfaces

…, T Nomura, T Arai, J Nakamura - Journal of …, 1997 - Wiley Online Library
The application of erbium:yag laser (Er:YAG) irradiation has been investigated for periodontal
therapy. The purpose of this study was to evaluate the effects of Er: YAG laser irradiation …

Complement activation products in the urine from proteinuric patients

Y Morita, H Ikeguchi, J Nakamura, N Hotta… - Journal of the …, 2000 - journals.lww.com
The presence of plasma proteins in the tubular lumen has variety of adverse effects on the
tubular cells. Among various plasma proteins filtered through glomerular barrier, complement …

Rapid formation of advanced glycation end products by intermediate metabolites of glycolytic pathway and polyol pathway

Y Hamada, N Araki, N Koh, J Nakamura… - Biochemical and …, 1996 - Elsevier
To clarify roles of intermediate metabolites of the glycolytic pathway and the polyol pathway
in nonenzymatic glycation under physiological conditions, we incubated bovine serum …

Safety and efficacy of oral semaglutide versus dulaglutide in Japanese patients with type 2 diabetes (PIONEER 10): an open-label, randomised, active-controlled …

D Yabe, J Nakamura, H Kaneto… - The Lancet Diabetes & …, 2020 - thelancet.com
Background New glucose-lowering medications need to be investigated in east Asian
populations, as the clinical characteristics of type 2 diabetes differ between western and east …

[HTML][HTML] Genome-wide association study of coronary artery disease in the Japanese

…, H Kitajima, H Rakugi, J Nakamura… - European journal of …, 2012 - nature.com
A new understanding of the genetic basis of coronary artery disease (CAD) has recently
emerged from genome-wide association (GWA) studies of common single-nucleotide …

Causes of death in Japanese patients with diabetes based on the results of a survey of 45,708 cases during 2001–2010: Report of the Committee on Causes of Death …

J Nakamura, H Kamiya, M Haneda… - Journal of diabetes …, 2017 - Wiley Online Library
The principal causes of death among 45,708 patients with diabetes (29,801 men and 15,907
women) who died in 241 hospitals throughout Japan during 2001–2010 were determined …