5′-Phosphate and 5′-phosphonate ester derivatives of (N)-methanocarba adenosine with in vivo cardioprotective activity

…, C Cronin, S Chakraborty, JB Shen… - Journal of medicinal …, 2013 - ACS Publications
Activation of a cardiac myocyte P2X4 receptor protects against heart failure. 5′-Phosphonate
and 5′-phosphate analogues of AMP containing a (N)-methanocarba (bicyclo[3.1.0]…

Digital holographic deep learning of red blood cells for field-portable, rapid COVID-19 screening

T O'Connor, JB Shen, BT Liang, B Javidi - Optics Letters, 2021 - opg.optica.org
Rapid screening of red blood cells for active infection of COVID-19 is presented using a
compact and field-portable, 3D-printed shearing digital holographic microscope. Video …

Comparison of L-type calcium channel blockade by nifedipine and/or cadmium in guinea pig ventricular myocytes

JB Shen, B Jiang, AJ Pappano - Journal of Pharmacology and Experimental …, 2000 - ASPET
We tested the assumption that nifedipine blocks L-type calcium current [I Ca(L) ] at +10 mV
and unmasks Na + /Ca 2+ exchange-triggered contractions in guinea pig isolated ventricular …

[HTML][HTML] P2X4 receptor–eNOS signaling pathway in cardiac myocytes as a novel protective mechanism in heart failure

R Yang, D Beqiri, JB Shen, JM Redden… - Computational and …, 2015 - Elsevier
We have demonstrated using immunoprecipitation and immunostaining a novel physical
association of the P2X4 receptor (P2X4R), a ligand-gated ion channel, with the cardioprotective…

Novel protective role of endogenous cardiac myocyte P2X4 receptors in heart failure

T Yang, J Shen, R Yang, J Redden… - Circulation: Heart …, 2014 - Am Heart Assoc
Background— Heart failure (HF), despite continuing progress, remains a leading cause of
mortality and morbidity. P2X4 receptors (P2X4R) have emerged as potentially important …

CD13 is essential for inflammatory trafficking and infarct healing following permanent coronary artery occlusion in mice

…, J Subramani, R Wang, JB Shen… - Cardiovascular …, 2013 - academic.oup.com
Aims To determine the role of CD13 as an adhesion molecule in trafficking of inflammatory
cells to the site of injury in vivo and its function in wound healing following myocardial …

Extracellular ATP‐stimulated current in wild‐type and P2X4 receptor transgenic mouse ventricular myocytes: implications for a cardiac physiologic role of P2X4 …

JB Shen, AJ Pappano, BT Liang - The FASEB Journal, 2006 - Wiley Online Library
P2X receptors, activated by extracellular ATP, may be important in regulating cardiac function.
The objective of the present study was to characterize the electrophysiologic actions of …

[HTML][HTML] SARS-CoV-2 antibody dynamics in healthcare workers after mRNA vaccination

KD Dieckhaus, MJ Kim, JB Shen, TS Liang… - Vaccines, 2023 - mdpi.com
Since the emergence of SARS-CoV-2, maintaining healthcare worker (HCW) health and
safety has been fundamental to responding to the global pandemic. Vaccination with mRNA-…

P2X purinergic receptor-mediated ionic current in cardiac myocytes of calsequestrin model of cardiomyopathy: implications for the treatment of heart failure

JB Shen, C Cronin, D Sonin, BV Joshi… - American Journal …, 2007 - journals.physiology.org
P2X purinergic receptors, activated by extracellular ATP, mediate a number of cardiac cellular
effects and may be important under pathophysiological conditions. The objective of the …

Treatment of heart failure by a methanocarba derivative of adenosine monophosphate: implication for a role of cardiac purinergic P2X receptors

SY Zhou, M Mamdani, K Qanud, JB Shen… - … of Pharmacology and …, 2010 - ASPET
Evidence is accumulating to support a potentially important role for purinergic (P2X)
receptors in heart failure (HF). We tested the hypothesis that a hydrolysis-resistant nucleotide …