Oscillating glucose is more deleterious to endothelial function and oxidative stress than mean glucose in normal and type 2 diabetic patients
A Ceriello, K Esposito, L Piconi, MA Ihnat, JE Thorpe… - Diabetes, 2008 - Am Diabetes Assoc
OBJECTIVE—To explore the possibility that oscillating glucose may outweigh A1C levels in
determining the risk for cardiovascular diabetes complications. RESEARCH DESIGN AND …
determining the risk for cardiovascular diabetes complications. RESEARCH DESIGN AND …
The “metabolic memory”: is more than just tight glucose control necessary to prevent diabetic complications?
A Ceriello, MA Ihnat, JE Thorpe - The Journal of Clinical …, 2009 - academic.oup.com
Context: The concept of a “metabolic memory,” that is of diabetic vascular stresses persisting
after glucose normalization, has been supported both in the laboratory and in the clinic and …
after glucose normalization, has been supported both in the laboratory and in the clinic and …
Chronic exposure to arsenic in the drinking water alters the expression of immune response genes in mouse lung
…, PL Eisenhauer, DJ Weiss, JE Thorpe… - Environmental …, 2009 - ehp.niehs.nih.gov
Background Chronic exposure to drinking water arsenic is a significant worldwide environmental
health concern. Exposure to As is associated with an increased risk of lung disease, …
health concern. Exposure to As is associated with an increased risk of lung disease, …
[HTML][HTML] Development and characterization of a preclinical model of breast cancer lung micrometastatic to macrometastatic progression
LC Bailey-Downs, JE Thorpe, BC Disch, A Bastian… - PloS one, 2014 - journals.plos.org
Most cancer patients die with metastatic disease, thus, good models that recapitulate the
natural process of metastasis including a dormancy period with micrometastatic cells would be …
natural process of metastasis including a dormancy period with micrometastatic cells would be …
Laboratory diet profoundly alters gene expression and confounds genomic analysis in mouse liver and lung
…, LA Warnke, JA Gosse, JC Davey, JE Thorpe… - Chemico-biological …, 2008 - Elsevier
Nutritional studies in laboratory animals have long shown that various dietary components
can contribute to altered gene expression and metabolism, but diet alone has not been …
can contribute to altered gene expression and metabolism, but diet alone has not been …
The design and discovery of water soluble 4-substituted-2, 6-dimethylfuro [2, 3-d] pyrimidines as multitargeted receptor tyrosine kinase inhibitors and microtubule …
X Zhang, S Raghavan, M Ihnat, JE Thorpe… - Bioorganic & medicinal …, 2014 - Elsevier
The design, synthesis and biological evaluations of fourteen 4-substituted 2,6-dimethylfuro[2,3-d]pyrimidines
are reported. Four compounds (11–13, 15) inhibit vascular endothelial …
are reported. Four compounds (11–13, 15) inhibit vascular endothelial …
Mutant p53 facilitates pro-angiogenic, hyperproliferative phenotype in response to chronic relative hypoxia
CD Kamat, DE Green, L Warnke, JE Thorpe, A Ceriello… - Cancer letters, 2007 - Elsevier
There is much controversy in the literature regarding the role of p53 status response on hypoxia
inducible factor (HIF) signaling in response to chronic relative hypoxia (CRH). The goal …
inducible factor (HIF) signaling in response to chronic relative hypoxia (CRH). The goal …
Synthesis and biological activity of N4-phenylsubstituted-6-(2, 4-dichloro phenylmethyl)-7H-pyrrolo [2, 3-d] pyrimidine-2, 4-diamines as vascular endothelial growth …
A Gangjee, S Kurup, MA Ihnat, JE Thorpe… - Bioorganic & medicinal …, 2010 - Elsevier
A series of eight N 4 -phenylsubstituted-6-(2,4-dichlorophenylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines
8–15 were synthesized as vascular endothelial growth factor receptor-2 (…
8–15 were synthesized as vascular endothelial growth factor receptor-2 (…
Discovery of antitubulin agents with antiangiogenic activity as single entities with multitarget chemotherapy potential
…, RK Pavana, MA Ihnat, JE Thorpe… - ACS medicinal …, 2014 - ACS Publications
Antiangiogenic agents (AA) are cytostatic, and their utility in cancer chemotherapy lies in
their combination with cytotoxic chemotherapeutic agents. Clinical combinations of vascular …
their combination with cytotoxic chemotherapeutic agents. Clinical combinations of vascular …
Exposure to arsenic at levels found in US drinking water modifies expression in the mouse lung
…, T Hampton, RA Mason, JE Thorpe… - Toxicological …, 2007 - academic.oup.com
The mechanisms of action of drinking water arsenic in the lung and the threshold for biologic
effects remain controversial. Our study utilizes Affymetrix 22,690 transcript oligonucleotide …
effects remain controversial. Our study utilizes Affymetrix 22,690 transcript oligonucleotide …