… To better understand the diametrically opposed regulation of food intake by α-MSH and
AgRP, we sought to identify mechanism(s) by which these peptides control firing activity of …

… The slope of the static ratio from 7 to 12 s was calculated, … Eight successive pulses to −120
mV, separated by a 5-s … 2 s and then returned to a holding potential of −25 mV for 5 s …

… For Kir current recordings, cells were voltage-clamped and stepped every 5 s from a holding
… 120 to 0 mV every 10 s. Slo1/β1 currents were recorded every 5 s after 200-ms voltage step …

The swelling-activated anion channel VRAC has fascinated and frustrated physiologists
since it was first described in 1988. Multiple laboratories have defined VRAC’s biophysical …

Insecticide resistance is a growing threat to mosquito control programs around the world,
thus creating the need to discover novel target sites and target-specific compounds for …

Abnormal uterine activity in pregnancy causes a range of important clinical disorders, including
preterm birth, dysfunctional labour and post‐partum haemorrhage. Uterine contractile …

Mosquito-borne diseases such as malaria and dengue fever take a large toll on global health.
The primary chemical agents used for controlling mosquitoes are insecticides that target …

Volume-regulated anion channels (VRACs) mediate volume regulatory Cl-and organic
solute efflux from vertebrate cells. VRACs are heteromeric assemblies of LRRC8A-E proteins …

Inward rectifier potassium (Kir) channels have been postulated as therapeutic targets for
several common disorders including hypertension, cardiac arrhythmias and pain. With few …

The inward rectifier potassium (Kir) channel Kir4.1 (KCNJ10) carries out important physiologic
roles in epithelial cells of the kidney, astrocytes in the central nervous system, and stria …