Angiotensin II and endothelin-1 activate their respective AT 1 and ET A receptors on vascular
smooth muscle cells, producing vasoconstriction, and both peptides are implicated in the …

INTRODUCTION: TAFI indirectly reduces the action of tPA on plasminogen. Whether exogenous
tPA is necessary for TAFI inhibitor efficacy is unclear. Potato carboxypeptidase inhibitor (…

Increased severity of glomerulonephritis in CC chemokine receptor 2 knockout mice.
Background The CC chemokine receptor 2 (CCR2) is expressed on monocytes and facilitates …

… We thank Xiaosui Jiang and Jergen Baumann for technical assistance, Dr. Yan Ma for
statistical assistance, Dr. Xiaoxin Qiao for preparing the HCl salt of prasugrel and Dr. …

Target levels of ex vivo inhibition of platelet aggregation (IPA) induced by adenosine diphosphate
(ADP) that produce clinically relevant effects of clopidogrel, a P2Y 12 antagonist, are …

… We thank Jeffrey Bostwick and Earl Crain for technical advice on thrombosis models, Anne
Stewart and Earl Crain for technical advice on bleeding models, and Jergen Baumann for …

Background: Optimal treatment of arterial thrombosis may include a combination of antiplatelet
and anticoagulant drugs. We evaluated apixaban, a direct and highly selective factor Xa …

The clinical course of inflammatory bowel disease (IBD) in dogs is characterized by spontaneous
exacerbations and remissions, which makes assessment of disease burden difficult. …

This coUection of short stories, essays, and poetry are written from a female perspective,
often about women in conflict: with themselves, with men, with society, with their roles. The …

Clinical indices, consisting of gastrointestinal signs and laboratory parameters, are widely
used for assessing disease activity in human inflammatory bowel disease (IBD). The …