A method is proposed for direct mapping of spectral density functions of the rotational motions
of HX bond vectors, such as 1 H 15 N, by measuring a set of NMR relaxation parameters…

Since the first report appeared in 19961 describing the use of NMR spectroscopy to screen
for potential drug molecules, the field of NMR-based screening has evolved rapidly. Over the …

Revised Manuscript Received June 10, 1992 abstract: A new strategy is used for studying
the internal motions of proteins based on measurements of NMR relaxation parameters. The …

The DNA binding domain (residues 1−65) of the yeast transcriptional activator GAL4 is only
partially folded. While residues 10−41, the DNA recognition domain, form a well-defined …

Rationale: Changes in airway epithelial cell differentiation, driven in part by IL-13, are important
in asthma. Micro-RNAs (miRNAs) regulate cell differentiation in many systems and could …

Publisher Summary This chapter discusses the 2D pulse sequences applicable for measuring
relaxation rates in singly protonated heteronuclear spin systems, such as 15 N- 1 H and …

Revised Manuscript Received October 12, 1995® abstract: The internal mobility of the protein
eglin c is characterized with spectral density functions of the NH vectors obtained from …

Background: Recently, it has been shown that nuclear magnetic resonance (NMR) may be
used to identify ligands that bind to low molecular weight protein drug targets. Recognizing …

Rationale: Sarcoidosis is a granulomatous disease of unknown etiology, although M.
tuberculosis may play a role in the pathogenesis. The traditional view holds that inflammation in …

In the past decade, the potential of harnessing the ability of nuclear magnetic resonance (NMR)
spectroscopy to monitor intermolecular interactions as a tool for drug discovery has been …