1,1,1,3,3,3-Hexafluoroisopropanol (HFIP) is a polar, strongly hydrogen bond-donating
solvent that has found numerous uses in organic synthesis due to its ability to stabilize ionic …

The world is chiral. Most of the molecules in it are chiral, and asymmetric synthesis is an
important means by which enantiopure chiral molecules may be obtained for study and sale. …

INTRODUCTION The microbiota promotes the maturation and homeostasis of the immune
system, in part through the release of microbial products. Early-life microbial colonization has …

The reaction of hydrazoic acid with ketones to afford a ring-expanded lactam (the Schmidt
reaction) is an important method for the preparation of nitrogen-containing heterocycles. 1 The …

Clinical development of orally active peptide drugs has been restricted by their unfavorable
physicochemical properties, which limit their intestinal mucosal permeation and their lack of …

The amide bond is one of the most important functional groups in chemistry and biology. 1
Due to the strong resonance interaction between nN and π* C O orbitals (Figure 1), 2 the …

Quaternary ammonium (QA) compounds inhibit K+ conductance by entering and occluding
the open pore of voltageactivated K+ channels. We characterized the effects of a series of …

Agonists targeting the kappa opioid receptor (KOR) have been promising therapeutic
candidates because of their efficacy for treating intractable itch and relieving pain. Unlike typical …

Cdc42 plays important roles in cytoskeleton organization, cell cycle progression, signal
transduction, and vesicle trafficking. Overactive Cdc42 has been implicated in the pathology of …

Small-molecule probes can illuminate biological processes and aid in the assessment of
emerging therapeutic targets by perturbing biological systems in a manner distinct from other …