AMG 837: a potent, orally bioavailable GPR40 agonist

…, Y Wang, J Liu, J Liu, JC Medina, JD Reagan… - Bioorganic & medicinal …, 2012 - Elsevier
The discovery that certain long chain fatty acids potentiate glucose stimulated insulin secretion
through the previously orphan receptor GPR40 sparked interest in GPR40 agonists as …

G-protein-coupled receptor 35 is a target of the asthma drugs cromolyn disodium and nedocromil sodium

…, X Wu, S Summer, J Whoriskey, C Saris, JD Reagan - Pharmacology, 2010 - karger.com
We report that the asthma drugs cromolyn disodium and nedocromil sodium are potent G-protein-coupled
receptor 35 (GPR35) agonists. We utilized calcium flux and inositol phosphate …

The psoriasis drug monomethylfumarate is a potent nicotinic acid receptor agonist

…, JYL Lu, X Zheng, Y Yang, JD Reagan - … and biophysical research …, 2008 - Elsevier
Nicotinic acid has been used for several decades to treat dyslipidemia. In mice, the lipid-lowing
effect of nicotinic acid is mediated by the Gi coupled receptor PUMA-G. In humans, high (…

[HTML][HTML] Elucidation of signaling and functional activities of an orphan GPCR, GPR81

H Ge, J Weiszmann, JD Reagan, J Gupte… - Journal of lipid …, 2008 - ASBMB
GPR81 is an orphan G protein-coupled receptor (GPCR) that has a high degree of homology
to the nicotinic acid receptor GPR109A. GPR81 expression is highly enriched and specific …

[HTML][HTML] AMG 837: a novel GPR40/FFA1 agonist that enhances insulin secretion and lowers glucose levels in rodents

…, XN Li, L Tang, GR Tonn, G Swaminath, JD Reagan… - PLoS …, 2011 - journals.plos.org
Agonists of GPR40 (FFA1) have been proposed as a means to treat type 2 diabetes. Through
lead optimization of a high throughput screening hit, we have identified a novel GPR40 …

[HTML][HTML] Expression cloning of an insect diuretic hormone receptor. A member of the calcitonin/secretin receptor family.

JD Reagan - Journal of Biological Chemistry, 1994 - Elsevier
Insect diuretic hormones and their receptors regulate fluid and ion secretion and thus are
attractive targets for the design of novel insect control agents. A complementary DNA clone …

Malonyl CoA decarboxylase inhibition improves cardiac function post-myocardial infarction

…, M Chaves, A Motani, JR Ussher, JD Reagan… - JACC: Basic to …, 2019 - jacc.org
Alterations in cardiac energy metabolism after a myocardial infarction contribute to the severity
of heart failure (HF). Although fatty acid oxidation can be impaired in HF, it is unclear if …

Novel small-molecule troponin activator increases cardiac contractile function without negative impact on energetics

…, JJ Hartman, FI Malik, JD Reagan… - Circulation: Heart …, 2022 - Am Heart Assoc
Background: Current heart failure therapies unload the failing heart without targeting the
underlying problem of reduced cardiac contractility. Traditional inotropes (ie, calcitropes) …

Potent and orally bioavailable GPR142 agonists as novel insulin secretagogues for the treatment of type 2 diabetes

…, F Nara, N Watanabe, JD Reagan… - ACS medicinal …, 2013 - ACS Publications
GPR142 is a G protein-coupled receptor that is predominantly expressed in pancreatic β-cells.
GPR142 agonists stimulate insulin secretion in the presence of high glucose …

The N-1-naphthylphthalamic acid-binding protein is an integral membrane protein

P Bernasconi, BC Patel, JD Reagan… - Plant …, 1996 - academic.oup.com
N-1-Naphthylphthalmic acid (NPA)-binding protein is a plasmalemma (PM) protein involved
in the control of cellular auxin efflux. We re-evaluated the spatial relationship of this protein …