In vitro p-glycoprotein inhibition assays for assessment of clinical drug interaction potential of new drug candidates: a recommendation for probe substrates
…, A Balakrishnan, JP Keogh, JR Kunta… - Drug metabolism and …, 2006 - ASPET
Because modulation of P-glycoprotein (Pgp) through inhibition or induction can lead to drug-drug
interactions by altering intestinal, central nervous system, renal, or biliary efflux, it is …
interactions by altering intestinal, central nervous system, renal, or biliary efflux, it is …
Effect of menthol and related terpenes on the percutaneous absorption of propranolol across excised hairless mouse skin
JR Kunta, VR Goskonda, HO Brotherton… - Journal of …, 1997 - Wiley Online Library
The potential use of terpenes/terpenoids as penetration enhancers in the transdermal delivery
of propranolol hydrochloride (PL) was investigated. PL was chosen for the reasons of its …
of propranolol hydrochloride (PL) was investigated. PL was chosen for the reasons of its …
Intestinal drug transporters: in vivo function and clinical importance
JR Kunta, PJ Sinko - Current Drug Metabolism, 2004 - ingentaconnect.com
The oral route of drug administration remains the most popular and convenient route of
administration, despite its many shortcomings and challenges. Although the advantages …
administration, despite its many shortcomings and challenges. Although the advantages …
Development, validation and utility of an in vitro technique for assessment of potential clinical drug–drug interactions involving P-glycoprotein
JP Keogh, JR Kunta - European journal of pharmaceutical sciences, 2006 - Elsevier
Regulatory interest is increasing for drug transporters generally and P-glycoprotein (Pgp) in
particular, primarily in the area of drug–drug interactions. To aid in both identifying and …
particular, primarily in the area of drug–drug interactions. To aid in both identifying and …
Differentiation of gut and hepatic first pass metabolism and secretion of saquinavir in ported rabbits
PJ Sinko, JR Kunta, HH Usansky, BA Perry - Journal of Pharmacology and …, 2004 - ASPET
The current study was performed in intestinal and vascular access ported rabbits to quantify
and differentiate the components of intestinal and hepatic first pass extraction (ie, …
and differentiate the components of intestinal and hepatic first pass extraction (ie, …
Differentiation of gut and hepatic first-pass effect of drugs: 1. Studies of verapamil in ported dogs
YH Lee, BA Perry, HS Lee, JR Kunta, JP Sutyak… - Pharmaceutical …, 2001 - Springer
Purpose. To investigate the relative contributions of the gut and liver to the first-pass loss of
verapamil (VL) using anin vivo intestinal-vascular access port (IVAP) dog model. Methods. …
verapamil (VL) using anin vivo intestinal-vascular access port (IVAP) dog model. Methods. …
Differentiation of gut and hepatic first-pass loss of verapamil in intestinal and vascular access-ported (IVAP) rabbits
Low and varied oral bioavailability (BA) of some drugs has been attributed to extraction by
the intestine and liver. However, the role of the intestine is difficult to directly assess. We …
the intestine and liver. However, the role of the intestine is difficult to directly assess. We …
Development of a novel intestinal and vascular access port (IVAP) rabbit model to study regiospecific oral absorption pharmacokinetics
JR Kunta, BA Perry, JP Sutyak… - Comparative …, 2001 - ingentaconnect.com
Background and Purpose: The limited availability and cost of many drugs prohibits routine
use of the previously developed intestinal and vascular access port (IVAP) canine model by …
use of the previously developed intestinal and vascular access port (IVAP) canine model by …
In vitro characterization of intestinal and hepatic transporters: MRP2
RV Alluri, P Ward, JR Kunta, BC Ferslew… - Optimization in Drug …, 2014 - Springer
The transporter field has grown extensively over the past decade. Analogous to drug
metabolizing enzymes such as the cytochrome P450s, transporters play a major role in defining …
metabolizing enzymes such as the cytochrome P450s, transporters play a major role in defining …
[BOOK][B] Investigation of the role of intestinal extraction on oral bioavailability
JR Kunta - 2002 - search.proquest.com
INFORMATION TO USERS Page 1 INFORMATION TO USERS This manuscript has been
reproduced from the microfilm master. UMI films the text directly from the original or copy …
reproduced from the microfilm master. UMI films the text directly from the original or copy …