Differential effects of naltrindole on morphine-induced tolerance and physical dependence in rats

MJ Hepburn, PJ Little, J Gingras, CM Kuhn - Journal of Pharmacology and …, 1997 - ASPET
This study investigated the effect of delta opioid receptor blockade by naltrindole on the
development of physical dependence and tolerance to the antinociceptive and respiratory …

Ultrasound diagnosis of fetal anomalies associated with in utero cocaine exposure: further support for cocaine-induced vascular disruption teratogenesis

RF Hume, Jr, JL Gingras, LS Martin… - Fetal diagnosis and …, 1994 - karger.com
The dramatic increase in cocaine use over the past decade has led to a concern about its
possible teratogenicity. We have identified 6 structural fetal anomalies which we postulate may …

[PDF][PDF] Clinical trial design for HMI-203 investigational gene therapy for mucopolysaccharidosis type II (MPS II) informed by cross-correction potential and KOL input

J Gingras, J Haroldson, LJ Smith, K Patel… - Abstracts/Molecular …, 2021 - researchgate.net
MPS II is a rare lysosomal disorder caused by mutations in the iduronate-2-sulfatase gene (IDS)
and results in an accumulation of glycosaminoglycans (GAGs). HMI-203 is an …

The influence of Alzheimer's disease stigma on pain assessment in older persons

V Vitou, MC Gély-Nargeot, C Jeandel, S Bayard - Dementia, 2022 - journals.sagepub.com
… the video clip with a unique label “Jeanine, 80 years old, with … Jeanine’s affective distress
scales (p < 0.001). No significant difference was found between the pain intensity and Jeanine’…

Co‐culture in cartilage tissue engineering

J Hendriks, J Riesle… - Journal of tissue …, 2007 - Wiley Online Library
For biotechnological research in vitro in general and tissue engineering specifically, it is
essential to mimic the natural conditions of the cellular environment as much as possible. In …

Judged by the (Digital) Company You Keep: Maintaining Judicial Ethics in an Age of Likes, Shares, and Follows

JG Browning - . Mary's J. on Legal Malpractice & Ethics, 2021 - HeinOnline
… included a "like" of a retweet by Fox News host Jeanine Pirro as well. … Gingras, and on
August 20, 2015-just one day after the trial's conclusion Judge Harrison liked a tweet by Gingras.1 …

Nav1.7 target modulation and efficacy can be measured in nonhuman primate assays

RL Kraus, F Zhao, PS Pall, D Zhou… - Science Translational …, 2021 - science.org
Humans with loss-of-function mutations in the Na v 1.7 channel gene (SCN9A) show profound
insensitivity to pain, whereas those with gain-of-function mutations can have inherited …

[HTML][HTML] Actopaxin (α-parvin) phosphorylation is required for matrix degradation and cancer cell invasion

J Pignatelli, SE LaLonde, DP LaLonde, D Clarke… - Journal of Biological …, 2012 - ASBMB
Dysregulation of cell adhesion and motility is known to be an important factor in the development
of tumor malignancy. Actopaxin (α-parvin) is a paxillin, integrin-linked kinase, and F-…

[HTML][HTML] Application of Pharmacokinetic-Pharmacodynamic Modeling to Inform Translation of In Vitro NaV1.7 Inhibition to In Vivo Pharmacological Response in Non …

JE Ballard, P Pall, J Vardigan, F Zhao… - Pharmaceutical …, 2020 - Springer
Purpose This work describes a staged approach to the application of pharmacokinetic-pharmacodynamic
(PK-PD) modeling in the voltage-gated sodium ion channel (NaV1.7) inhibitor …

Gender equity in health research publishing in Africa

A Baobeid, T Faghani-Hamadani, S Sauer, Y Boum… - BMJ Global …, 2022 - gh.bmj.com
Introduction Women researchers find it more difficult to publish in academic journals than
men, an inequity that affects women’s careers and was exacerbated during the pandemic, …