Hepatic glucokinase (GK) catalyzes the phosphorylation of glucose to glucose 6-phosphate
(G6P), a step which is essential for glucose metabolism in liver as well as for the induction of …

Dietary polyunsaturated fatty acids (PUFAs) are potent inhibitors of hepatic glycolysis and
lipogenesis. Recently, carbohydrate-responsive element–binding protein (ChREBP) was …

The last decade provided evidence that major (glucose, fatty acids, amino acids) or minor (iron,
vitamin, etc.) dietary constituents regulated gene expression in an hormonal-…

In addition to their ligand-mediated activation, nuclear receptor activity is finely tuned by their
phosphorylation status. PPARs are phosphorylated by several kinases (PKA, PKC, MAPKs, …

The short-term effect of metformin on fatty acid and glucose metabolism was studied in freshly
incubated hepatocytes from 24-hr starved rats. Metformin (5 or 50 mM) had no effect on …

The Wnt/β‐catenin signaling pathway has been increasingly implicated in liver development
and physiology. Aberrant activation of this pathway is one of the major genetic events …

Liver carnitine palmitoyltransferase I (L-CPT I) catalyses the transfer of long-chain fatty acid (LCFA)
for translocation across the mitochondrial membrane. Expression of the L-CPT I gene …

Glucose and fatty acid metabolism (oxidation versus esterification) has been measured in
hepatocytes isolated from 24 h starved peroxisome proliferator-activated receptor-α (PPARα) …

The mRNA and the activity of glucose-6-phosphatase (Glc-6-Pase) were present in the liver,
kidney, and small intestine of 15-day-old suckling rats, but were absent from the stomach, …

In the rat, the gene for liver mitochondrial carnitine palmitoyltransferase I (CPT I), though
dormant prior to birth, is rapidly activated postnatally. We sought to elucidate which hormonal …