Adipocytes sequester and metabolize the chemotherapeutic daunorubicin
X Sheng, JH Parmentier, J Tucci, H Pei… - Molecular cancer …, 2017 - AACR
Obesity is associated with poorer outcome for many cancers. Previously, we observed that
adipocytes protect acute lymphoblastic leukemia (ALL) cells from the anthracycline, …
adipocytes protect acute lymphoblastic leukemia (ALL) cells from the anthracycline, …
Glutaminase activity determines cytotoxicity of L-asparaginases on most leukemia cell lines
l-Asparaginase (ASNase) is a front-line chemotherapy for acute lymphoblastic leukemia (ALL),
which acts by deaminating asparagine and glutamine. To evaluate the importance of …
which acts by deaminating asparagine and glutamine. To evaluate the importance of …
Adipose tissue inflammation in breast cancer survivors: effects of a 16-week combined aerobic and resistance exercise training intervention
CM Dieli-Conwright, JH Parmentier, N Sami… - Breast cancer research …, 2018 - Springer
Purpose Obesity is a leading modifiable contributor to breast cancer mortality due to its
association with increased recurrence and decreased overall survival rate. Obesity stimulates …
association with increased recurrence and decreased overall survival rate. Obesity stimulates …
Angiotensin II–induced hypertension: contribution of ras GTPase/mitogen-activated protein kinase and cytochrome P450 metabolites
…, Z Khandekar, IF Benter, AE Saeed, JH Parmentier… - …, 2000 - Am Heart Assoc
We reported that norepinephrine and angiotensin II (Ang II) activate the Ras/mitogen-activated
protein (MAP) kinase pathway primarily through the generation of cytochrome P450 (…
protein (MAP) kinase pathway primarily through the generation of cytochrome P450 (…
[HTML][HTML] Functional interaction of calcium-/calmodulin-dependent protein kinase II and cytosolic phospholipase A2
…, S Canaan, J Harper, H Zhou, JH Parmentier… - Journal of Biological …, 2001 - ASBMB
Calcium-/calmodulin-dependent protein kinase II (CaM kinase II), a decoder of Ca 2+ signals,
and cytosolic phospholipase A 2 (cPLA 2 ), an enzyme involved in arachidonate release, …
and cytosolic phospholipase A 2 (cPLA 2 ), an enzyme involved in arachidonate release, …
[HTML][HTML] Adipocytes cause leukemia cell resistance to daunorubicin via oxidative stress response
X Sheng, J Tucci, JH Parmentier, L Ji, JW Behan… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Adipocytes promote cancer progression and impair treatment, and have been shown to
protect acute lymphoblastic leukemia (ALL) cells from chemotherapies. Here we investigate …
protect acute lymphoblastic leukemia (ALL) cells from chemotherapies. Here we investigate …
[HTML][HTML] A protease-resistant Escherichia coli asparaginase with outstanding stability and enhanced anti-leukaemic activity in vitro
L-Asparaginases (ASNases) have been used as first line drugs for paediatric Acute Lymphoblastic
Leukaemia (ALL) treatment for more than 40 years. Both the Escherichia coli (EcAII) …
Leukaemia (ALL) treatment for more than 40 years. Both the Escherichia coli (EcAII) …
[HTML][HTML] Phospholipase D activation by norepinephrine is mediated by 12 (S)-, 15 (S)-, and 20-hydroxyeicosatetraenoic acids generated by stimulation of cytosolic …
JH Parmentier, MM Muthalif, AE Saeed… - Journal of Biological …, 2001 - ASBMB
Norepinephrine (NE) stimulates phospholipase D (PLD) through a Ras/MAPK pathway in
rabbit vascular smooth muscle cells (VSMC). NE also activates calcium influx and calmodulin (…
rabbit vascular smooth muscle cells (VSMC). NE also activates calcium influx and calmodulin (…
Contribution of Ras GTPase/MAP kinase and cytochrome P450 metabolites to deoxycorticosterone-salt–induced hypertension
…, L Gaber, A Estes, S Malik, JH Parmentier… - …, 2000 - Am Heart Assoc
We recently reported that norepinephrine and angiotensin II activate the Ras/mitogen-activated
protein (MAP) kinase pathway through generation of a cytochrome P450 (CYP450) and …
protein (MAP) kinase pathway through generation of a cytochrome P450 (CYP450) and …
Alpha-1A adrenergic receptor stimulation with phenylephrine promotes arachidonic acid release by activation of phospholipase D in rat-1 fibroblasts: inhibition by …
Y Ruan, H Kan, JH Parmentier, S Fatima… - … of Pharmacology and …, 1998 - ASPET
This study was conducted to determine the mechanism of arachidonic acid (AA) release
elicited by phenylephrine (PHE) stimulation ofalpha adrenergic receptor (AR), and its …
elicited by phenylephrine (PHE) stimulation ofalpha adrenergic receptor (AR), and its …