Chronic dietary α-linolenic acid deficiency alters dopaminergic and serotoninergic neurotransmission in rats

…, S Chalon, J Hérault, D Guilloteau, JC Besnard… - The Journal of …, 1994 - Elsevier
This study examined the effects of dietary α-linolenic acid [18:3(n-3)] deficiency on dopaminergic
and serotoninergic neurotransmission systems in 60-d-old male rats. Rats were fed …

α‐Linolenic acid dietary deficiency alters age‐related changes of dopaminergic and serotoninergic neurotransmission in the rat frontal cortex

…, S Chalon, D Guilloteau, JC Besnard… - Journal of …, 1996 - Wiley Online Library
The effects of α‐linolenic acid diet deficiency on rat dopaminergic and serotoninergic
neurotransmission systems were investigated in the frontal cortex, striatum, and cerebellum of male …

[HTML][HTML] Dietary fish oil affects monoaminergic neurotransmission and behavior in rats

…, D Guilloteau, AM Leguisquet, JC Besnard… - The Journal of …, 1998 - Elsevier
We studied the effects of a fish oil enriched diet on fatty acid composition of cerebral membranes
and on several neurochemical and behavioral variables of monoaminergic function in …

[HTML][HTML] Modification of dopamine neurotransmission in the nucleus accumbens of rats deficient in n–3 polyunsaturated fatty acids

…, G Durand, D Guilloteau, S Bodard, JC Besnard… - Journal of lipid …, 2000 - ASBMB
We studied the effects of a diet chronically deficient in α-linolenic acid, the precursor of long-chain
n–3 polyunsaturated fatty acids, on dopaminergic neurotransmission in the shell …

Serotoninergic neurotransmission is affected by n‐3 polyunsaturated fatty acids in the rat

…, S Vancassel, D Guilloteau, JC Besnard… - Journal of …, 2004 - Wiley Online Library
We explored the effects of chronic α‐linolenic acid dietary deficiency on serotoninergic
neurotransmission. In vivo synaptic serotonin (5‐HT) levels were studied in basal and …

Partial recovery of dopaminergic pathway after graft of adult mesenchymal stem cells in a rat model of Parkinson's disease

…, A Rico, D Guilloteau, P Charbord, JC Besnard… - Neurochemistry …, 2008 - Elsevier
Cellular therapy with adult stem cells appears as an opportunity for treatment of Parkinson's
disease. To validate this approach, we studied the effects of transplantation of rat adult bone-…

Synthesis and Ligand Binding of Nortropane Derivatives:  N-Substituted 2β-Carbomethoxy-3β-(4'-iodophenyl)nortropane and N-(3-Iodoprop-(2E)-enyl)-2β …

…, Y Frangin, L Mauclaire, JC Besnard… - Journal of medicinal …, 1997 - ACS Publications
Two novel series of iodinated N-substituted analogs of 2β-carbomethoxy-3β-(4‘-iodophenyl)tropane
(β-CIT) and N-(3-iodoprop-(2E)-enyl)-2β-carbomethoxy-3β-(3‘,4‘-disubstituted …

Age-related changes in phospholipid fatty acid composition and monoaminergic neurotransmission in the hippocampus of rats fed a balanced or an n-3 …

…, S Chalon, D Guilloteau, B Lejeune, JC Besnard… - Journal of lipid …, 1997 - ASBMB
The influence of aging (2, 6, 12, and 24 months) on hippocampal lipid composition and
neurochemical markers (endogenous noradrenaline, serotonin levels, monoamine oxidase (MOA…

Exploration of the dopamine transporter: in vitro and in vivo characterization of a high-affinity and high-specificity iodinated tropane derivative (E)-N-(3-iodoprop-2-enyl …

…, L Pourcelot, L Mauclaire, JC Besnard… - Nuclear medicine and …, 1998 - Elsevier
For the diagnosis and follow-up of neurodegenerative diseases, many cocaine derivatives
have been proposed as radioligands to explore the dopamine transporter. As none of them …

Pharmacological characterization of (E)-N-(4-fluorobut-2-enyl)-2β-carbomethoxy-3β-(4′-tolyl) nortropane (LBT-999) as a highly promising fluorinated ligand for the …

…, S Bodard, Z Mincheva, JC Besnard… - … of Pharmacology and …, 2006 - ASPET
In the aim to develop an efficient fluorinated probe for positron emission tomography (PET)
exploration of the dopamine transporter (DAT), we studied several in vitro and in vivo …