Metabolism of trichloroethylene.
…, JW Fisher, JC Lipscomb, JC Parker - Environmental health …, 2000 - ehp.niehs.nih.gov
A major focus in the study of metabolism and disposition of trichloroethylene (TCE) is to identify
metabolites that can be used reliably to assess flux through the various pathways of TCE …
metabolites that can be used reliably to assess flux through the various pathways of TCE …
Hepatic and renal toxicities associated with perchloroethylene
LH Lash, JC Parker - Pharmacological reviews, 2001 - ASPET
Metabolism of perchloroethylene (Perc) occurs by cytochrome P450-dependent oxidation
and glutathione (GSH) conjugation. The cytochrome P450 pathway generates tri- and …
and glutathione (GSH) conjugation. The cytochrome P450 pathway generates tri- and …
Apartment residents' and day care workers' exposures to tetrachloroethylene and deficits in visual contrast sensitivity.
…, K Langguth, EJ Prohonic, JC Parker - Environmental …, 2002 - ehp.niehs.nih.gov
Tetrachloroethylene (also called perchloroethylene, or perc), a volatile organic compound,
has been the predominant solvent used by the dry-cleaning industry for many years. The US …
has been the predominant solvent used by the dry-cleaning industry for many years. The US …
Modes of action of trichloroethylene for kidney tumorigenesis.
LH Lash, JC Parker, CS Scott - Environmental health …, 2000 - ehp.niehs.nih.gov
This article focuses on the various models for kidney toxicity due to trichloroethylene (TCE)
and its glutathione-dependent metabolites, in particular S-(1,2-dichlorovinyl)-l-cysteine. …
and its glutathione-dependent metabolites, in particular S-(1,2-dichlorovinyl)-l-cysteine. …
Glutathione-dependent metabolism of trichloroethylene in isolated liver and kidney cells of rats and its role in mitochondrial and cellular toxicity.
…, Y Xu, AA Elfarra, RJ Duescher, JC Parker - Drug metabolism and …, 1995 - ASPET
Metabolism of trichloroethylene (Tri) by the glutathione (GSH) conjugation pathway was
studied in hepatocytes, renal cortical cells, and liver subcellular fractions from male Fischer 344 …
studied in hepatocytes, renal cortical cells, and liver subcellular fractions from male Fischer 344 …
Renal and hepatic toxicity of trichloroethylene and its glutathione-derived metabolites in rats and mice: sex-, species-, and tissue-dependent differences
…, SE Hueni, AA Elfarra, RJ Krause, JC Parker - … of Pharmacology and …, 2001 - ASPET
Acute cytotoxicity (lactate dehydrogenase release) of trichloroethylene (TRI), S-(1,2-dichlorovinyl)glutathione
(DCVG), andS-(1,2-dichlorovinyl)-l-cysteine (DCVC) in freshly isolated …
(DCVG), andS-(1,2-dichlorovinyl)-l-cysteine (DCVC) in freshly isolated …
Glutathione conjugation of trichloroethylene in rats and mice: sex-, species-, and tissue-dependent differences
…, K Jacobs, AA Elfarra, RJ Krause, JC Parker - Drug metabolism and …, 1998 - ASPET
Glutathione (GSH) conjugation of trichloroethylene (Tri) to formS-(1,2-dichlorovinyl)glutathione
(DCVG) has been implicated in the nephrotoxicity and nephrocarcinogenicity of Tri. …
(DCVG) has been implicated in the nephrotoxicity and nephrocarcinogenicity of Tri. …
Metabolism and tissue distribution of orally administered trichloroethylene in male and female rats: identification of glutathione-and cytochrome P-450-derived …
LH Lash, DA Putt, JC Parker - Journal of Toxicology and …, 2006 - Taylor & Francis
Male and female Fischer 344 rats were administered trichloroethylene (TRI) (2, 5, or 15
mmol/kg body weight) in corn oil by oral gavage, and TRI and its metabolites were measured at …
mmol/kg body weight) in corn oil by oral gavage, and TRI and its metabolites were measured at …
Modulation of hepatic and renal metabolism and toxicity of trichloroethylene and perchloroethylene by alterations in status of cytochrome P450 and glutathione
LH Lash, DA Putt, P Huang, SE Hueni, JC Parker - Toxicology, 2007 - Elsevier
The relative importance of metabolism of trichloroethylene (Tri) and perchloroethylene (Perc)
by the cytochrome P450 (P450) and glutathione (GSH) conjugation pathways in their acute …
by the cytochrome P450 (P450) and glutathione (GSH) conjugation pathways in their acute …
Glutathione conjugation of trichloroethylene in human liver and kidney: kinetics and individual variation
LH Lash, JC Lipscomb, DA Putt, JC Parker - Drug metabolism and …, 1999 - ASPET
Isolated human hepatocytes exhibited time-, trichloroethylene (Tri) concentration-, and cell
concentration-dependent formation ofS-(1,2-dichlorovinyl)glutathione (DCVG) in incubations …
concentration-dependent formation ofS-(1,2-dichlorovinyl)glutathione (DCVG) in incubations …