(-)-Epicatechin gallate (ECG) is one of the flavonoids in green tea, which has been demonstrated
to have cancer-preventive properties in many model systems. However, the extent and …

Purpose: Tea flavonoids, including (–)-epicatechin (EC), have been suggested to have
chemopreventive properties in cancer. However, there is limited knowledge of the oral …

(−)-Epicatechin (EC) is one of the flavonoids present in green tea, suggested to have
chemopreventive properties in cancer. However, its bioavailability is not clearly understood. In the …

Abstract Evaluation of organic anion transporting polypeptide (OATP) 1B1–mediated drug‐drug
interactions (DDIs) is an integral part of drug development and is recommended by …

The FDA guidance on application of the biopharmaceutics classification system (BCS) for
waiver of in vivo bioequivalence (BE) studies was issued in August 2000. Since then, this …

There is over a hundred years of clinical experience with insulin for the treatment of diabetes.
The US Food and Drug Administration (FDA) approved the first insulin biosimilar …

The workshop “Drug Permeability - Best Practices for Biopharmaceutics Classification
System (BCS) Based Biowaivers” was held virtually on December 6, 2021, organized by the …

Theoretically, the risk of food effects for extended-release (ER) products compared to IR
products may be less because: (1) postprandial physiological changes are usually transient and …

The study evaluated whether the renal function decline rate per year with age in adults varies
based on two primary statistical analyses: cross‐section (CS), using one observation per …

Type 2 diabetes results when insulin secretion is unable to keep the plasma glucose levels
as per acceptable range. This leads to chronic hyperglycemia and its associated …