Increased locomotor activity induced by heroin in mice: pharmacokinetic demonstration of heroin acting as a prodrug for the mediator 6-monoacetylmorphine in vivo

JM Andersen, Å Ripel, F Boix, PT Normann… - Journal of Pharmacology …, 2009 - ASPET
We investigated the relative importance of heroin and its metabolites in eliciting a behavioral
response in mice by studying the relationship between concentrations of heroin, 6-…

Determination of heroin and its main metabolites in small sample volumes of whole blood and brain tissue by reversed-phase liquid chromatography-tandem mass …

R Karinen, JM Andersen, Å Ripel… - Journal of analytical …, 2009 - academic.oup.com
A high-performance liquid chromatography-tandem mass spectrometry (LC-MS-MS) method
has been developed for the quantitative analysis of heroin and its major metabolites 6-…

[HTML][HTML] Prenatal exposure to methadone or buprenorphine and long-term outcomes: a meta-analysis

JM Andersen, G Høiseth, E Nygaard - Early human development, 2020 - Elsevier
Aim To combine meta-analyses of multiple long-term outcomes in children prenatally exposed
to methadone or buprenorphine through their mothers' Opioid maintenance therapy (OMT…

[HTML][HTML] Prenatal exposure to methadone or buprenorphine impairs cognitive performance in young adult rats

M Kongstorp, IL Bogen, T Stiris, JM Andersen - Drug and Alcohol …, 2020 - Elsevier
Background Concerns have been raised about the use of opioid maintenance treatment (OMT)
during pregnancy and negative effects for the offspring. While neonatal outcomes and …

The effect of polychlorinated biphenyls on the uptake of dopamine and other neurotransmitters into rat brain synaptic vesicles

E Mariussen, JM Andersen, F Fonnum - Toxicology and applied …, 1999 - Elsevier
Studies have shown that polychlorinated biphenyls may affect cognitive functions both in
human and also in experimental animals. One of the neurochemical parameters that is …

[HTML][HTML] Chicken embryo as animal model to study drug distribution to the developing brain

D Zosen, MG Hadera, JS Lumor, JM Andersen… - … of pharmacological and …, 2021 - Elsevier
Introduction Rodent models are routinely used to assess the safety and developmental
toxicity of pharmaceuticals, along with analysis of their distribution. These models require …

A monoclonal antibody specific for 6-monoacetylmorphine reduces acute heroin effects in mice

…, F Boix, E Nerem, J Mørland, JM Andersen - Journal of Pharmacology …, 2014 - ASPET
Immunotherapy against drugs of abuse is being studied as an alternative treatment option
in addiction medicine and is based on antibodies sequestering the drug in the bloodstream …

High accumulation of methadone compared with buprenorphine in fetal rat brain after maternal exposure

M Kongstorp, IL Bogen, T Stiris, JM Andersen - Journal of Pharmacology and …, 2019 - ASPET
Experimental animal studies are valuable in revealing a causal relationship between
prenatal exposure to opioid maintenance treatment (OMT) and subsequent effects; however, …

Prenatal exposure to methadone or buprenorphine alters µ‐opioid receptor binding and downstream signaling in the rat brain

…, TW Salih, T Stiris, JM Andersen - International Journal …, 2020 - Wiley Online Library
There is a growing concern related to the use of opioid maintenance treatment during
pregnancy. Studies in both humans and animals have reported reduced cognitive functioning in …

[HTML][HTML] Comparative neuropharmacology and pharmacokinetics of methamphetamine and its thiophene analog methiopropamine in rodents

SS Tuv, MSS Bergh, JM Andersen… - International Journal of …, 2021 - mdpi.com
Methiopropamine is a novel psychoactive substance (NPS) that is associated with several
cases of clinical toxicity, yet little information is available regarding its neuropharmacological …