Increased locomotor activity induced by heroin in mice: pharmacokinetic demonstration of heroin acting as a prodrug for the mediator 6-monoacetylmorphine in vivo
JM Andersen, Å Ripel, F Boix, PT Normann… - Journal of Pharmacology …, 2009 - ASPET
We investigated the relative importance of heroin and its metabolites in eliciting a behavioral
response in mice by studying the relationship between concentrations of heroin, 6-…
response in mice by studying the relationship between concentrations of heroin, 6-…
Determination of heroin and its main metabolites in small sample volumes of whole blood and brain tissue by reversed-phase liquid chromatography-tandem mass …
R Karinen, JM Andersen, Å Ripel… - Journal of analytical …, 2009 - academic.oup.com
A high-performance liquid chromatography-tandem mass spectrometry (LC-MS-MS) method
has been developed for the quantitative analysis of heroin and its major metabolites 6-…
has been developed for the quantitative analysis of heroin and its major metabolites 6-…
[HTML][HTML] Prenatal exposure to methadone or buprenorphine and long-term outcomes: a meta-analysis
Aim To combine meta-analyses of multiple long-term outcomes in children prenatally exposed
to methadone or buprenorphine through their mothers' Opioid maintenance therapy (OMT…
to methadone or buprenorphine through their mothers' Opioid maintenance therapy (OMT…
[HTML][HTML] Prenatal exposure to methadone or buprenorphine impairs cognitive performance in young adult rats
M Kongstorp, IL Bogen, T Stiris, JM Andersen - Drug and Alcohol …, 2020 - Elsevier
Background Concerns have been raised about the use of opioid maintenance treatment (OMT)
during pregnancy and negative effects for the offspring. While neonatal outcomes and …
during pregnancy and negative effects for the offspring. While neonatal outcomes and …
The effect of polychlorinated biphenyls on the uptake of dopamine and other neurotransmitters into rat brain synaptic vesicles
E Mariussen, JM Andersen, F Fonnum - Toxicology and applied …, 1999 - Elsevier
Studies have shown that polychlorinated biphenyls may affect cognitive functions both in
human and also in experimental animals. One of the neurochemical parameters that is …
human and also in experimental animals. One of the neurochemical parameters that is …
[HTML][HTML] Chicken embryo as animal model to study drug distribution to the developing brain
Introduction Rodent models are routinely used to assess the safety and developmental
toxicity of pharmaceuticals, along with analysis of their distribution. These models require …
toxicity of pharmaceuticals, along with analysis of their distribution. These models require …
A monoclonal antibody specific for 6-monoacetylmorphine reduces acute heroin effects in mice
…, F Boix, E Nerem, J Mørland, JM Andersen - Journal of Pharmacology …, 2014 - ASPET
Immunotherapy against drugs of abuse is being studied as an alternative treatment option
in addiction medicine and is based on antibodies sequestering the drug in the bloodstream …
in addiction medicine and is based on antibodies sequestering the drug in the bloodstream …
High accumulation of methadone compared with buprenorphine in fetal rat brain after maternal exposure
M Kongstorp, IL Bogen, T Stiris, JM Andersen - Journal of Pharmacology and …, 2019 - ASPET
Experimental animal studies are valuable in revealing a causal relationship between
prenatal exposure to opioid maintenance treatment (OMT) and subsequent effects; however, …
prenatal exposure to opioid maintenance treatment (OMT) and subsequent effects; however, …
Prenatal exposure to methadone or buprenorphine alters µ‐opioid receptor binding and downstream signaling in the rat brain
…, TW Salih, T Stiris, JM Andersen - International Journal …, 2020 - Wiley Online Library
There is a growing concern related to the use of opioid maintenance treatment during
pregnancy. Studies in both humans and animals have reported reduced cognitive functioning in …
pregnancy. Studies in both humans and animals have reported reduced cognitive functioning in …
[HTML][HTML] Comparative neuropharmacology and pharmacokinetics of methamphetamine and its thiophene analog methiopropamine in rodents
SS Tuv, MSS Bergh, JM Andersen… - International Journal of …, 2021 - mdpi.com
Methiopropamine is a novel psychoactive substance (NPS) that is associated with several
cases of clinical toxicity, yet little information is available regarding its neuropharmacological …
cases of clinical toxicity, yet little information is available regarding its neuropharmacological …