Observations on the acute intravenous toxicity of a series of 3, 5-diacylamino-2,4,6-triiodobenzoic
acids in mice were presented. The least toxic compound of this series was found to be …

The acid-catalyzed methanolysis and hydrolysis of 2, 2-dimethyl-l-(3-aminopropyl)-ethyleneimine
led in each case to cleavage of the bond between the tertiary carbon and the nitrogen …

An objective method has been described for determining the irritant properties of
substances designed for parenteral administration by means of the trypan blue test. Various …

The local anesthetic activity, toxicity, and irritancy of mepivacaine HCl 1 (1-methyl-2′,6′-pipecoloxylidide
hydrochloride) and a solution (solution B) containing 2.0% mepivacaine HCl …

The search for a means of visualizing the chambers of the heart and the blood vessels on x-ray
film began almost simultaneously with the discovery of cholecystography and the develop…

1. WIN 2747 produced complete arrest of nerve-impulse transmission in the dog nerve-muscle
preparation at dosages approximately one-half the dose of d-tubocurarine chloride …

1. WIN 2848 is a highly active antagonist of histamine and is more potent in its antihistaminic
actions than are the chioro- and bromo- substituted analogs, WIN 2875 and WIN 2876. 2. …

1. The comparative acute intravenous toxicity in mice of sodium bisulfite in distilled water
and in 6 per cent protein hydrolysate was found to be 130 ± 8 and 130 ± 10 mgm./kgm., …

METHOD Adult albino rats weighing between 150 and 220 grams were in uniform dose of 2
million Trypanosoma equiperdum parasites acc method of Morrell, Chapman and Allmark (…

Correlation studies were carried out between local anesthetic activity and systemic toxicity
and between the former and irritancy. A very high correlation coefficient (r = 0.97) was found …