BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator

…, W Greenfield, SM Ruben, HS Olsen, J Fikes… - Science, 1999 - science.org
The tumor necrosis factor (TNF) superfamily of cytokines includes both soluble and
membrane-bound proteins that regulate immune responses. A member of the human TNF family, …

Use of severity grades to characterize histopathologic changes

KA Schafer, J Eighmy, JD Fikes… - Toxicologic …, 2018 - journals.sagepub.com
The severity grade is an important component of a histopathologic diagnosis in a nonclinical
toxicity study that helps distinguish treatment-related effects from background findings and …

Organophosphorus and carbamate insecticides

JD Fikes - Veterinary Clinics of North America: Small Animal …, 1990 - Elsevier
… 2, March 1990 Organophosphorus and Carbamate Insecticides James D. … James, Acute
pancreatitis induced by acute organophosphate poisoning Postgrad Med J 57: (1981) 660-662 …

Role of TL1A in the pathogenesis of rheumatoid arthritis

…, X Wang, H Fahmi, S Wojcik, J Fikes… - The Journal of …, 2009 - journals.aai.org
TNF-like ligand 1A (TL1A), a member of the TNF superfamily, is the ligand of DR3 and DcR3.
Several types of cells, such as endothelial cells, monocytes/macrophages, dendritic cells, …

[PDF][PDF] Identification of a novel simian parvovirus in cynomolgus monkeys with severe anemia. A paradigm of human B19 parvovirus infection.

MG O'Sullivan, DC Anderson, JD Fikes… - The Journal of …, 1994 - Am Soc Clin Investig
Although human B19 parvovirus infection has been clearly associated with a number of
distinct syndromes (including severe anemia, abortion, and arthritis), detailed knowledge of its …

In vivo inhibition of Fas ligand-mediated killing by TR6, a Fas ligand decoy receptor

K Connolly, YH Cho, R Duan, J Fikes, T Gregorio… - … of Pharmacology and …, 2001 - ASPET
TR6, a member of the tumor necrosis factor (TNF) receptor superfamily, has recently been
shown to bind to Fas ligand (FasL) and inhibit FasL-mediated cell killing in vitro. In the current …

Assessment of cisplatin-induced kidney injury using an integrated rodent platform

…, H Kamendi, H Barthlow, D Lengel, J Fikes… - Toxicology and applied …, 2013 - Elsevier
Current diagnosis of drug-induced kidney injury (DIKI) primarily relies on detection of elevated
plasma creatinine (Cr) or blood urea nitrogen (BUN) levels; however, both are indices of …

Pharmacokinetics and immunological effects of exogenously administered recombinant human B lymphocyte stimulator (BLyS) in mice

…, RC Miceli, CM Poortman, L Sekut, Y Li, J Fikes… - … of Pharmacology and …, 2001 - ASPET
B lymphocyte stimulator (BLyS; also known as TNFSF20, BAFF, TALL-1, zTNF4, and THANK),
a tumor necrosis factor ligand family member, has recently been identified as a factor that …

Antisense oligonucleotide-related macrovesicular vacuolation of hippocampal neurons in nonhuman primates

…, TF Magee, SP Henry, JD Fikes - Toxicologic …, 2022 - journals.sagepub.com
2′-methoxyethyl (MOE) antisense oligonucleotides (ASOs) tested in multidose intrathecal
nonhuman primate (NHP) toxicity studies have consistently revealed the presence of single …

Scientific and Regulatory Policy Committee review: review of the Organisation for Economic Co-operation and Development (OECD) guidance on the GLP …

JD Fikes, DJ Patrick, S Francke… - Toxicologic …, 2015 - journals.sagepub.com
In 2014, the Organisation for Economic Co-operation and Development (OECD) issued
guidance no. 16, Guidance on the GLP Requirements for Peer Review of Histopathology. The …