M 1 muscarinic acetylcholine receptors (mAChRs) represent a viable target for treatment of
multiple disorders of the central nervous system (CNS) including Alzheimer's disease and …

Parkinson's disease (PD) is a debilitating neurodegenerative disorder associated with
severe motor impairments caused by the loss of dopaminergic innervation of the striatum. …

Profiling of putative lead compounds against a representative panel of relevant enzymes,
receptors, ion channels, and transporters is a pragmatic approach to establish a preliminary …

Parkinson9s disease (PD) is a debilitating neurodegenerative disorder associated with
severe motor impairments caused by the loss of dopaminergic innervation of the striatum. …

Nicotinic acetylcholine receptors (nAChRs) form ligand-gated ion channels that mediate fast
signal transmission at synapses. These receptors are members of a large family of …

Background: Pharmacodynamics (PD) endpoint assays are important biomarker(s) for target
therapy/personalized medicine in oncology drug discovery & development. Identification of …

This study was designed to elucidate the selectivity and cellular behavior of several marketed
kinase inhibitors used in the treatment of cancer patients. Generally, kinase inhibitors are …

The epiblast of young chick embryos of stages 4–8 (Hamburger and Hamilton) was investigated
by scanning electron microscopy. On the basis of surface differentiation, two zones can …

Gingipains are cysteine proteinases acting as key virulence factors of the bacterium
Porphyromonas gingivalis, the major pathogen in periodontal disease. The 1.5 and 2.0 Å crystal …

Background: Trimeresurus stejnejeri venom plasminogen activator (TSV-PA) is a snake
venom serine proteinase that specifically activates plasminogen. Snake venom serine …