A gradient-loadable 64Cu-chelator for quantifying tumor deposition kinetics of nanoliposomal therapeutics by positron emission tomography
…, E Geretti, J Hesterman, C Harwell, J Hoppin… - … , Biology and Medicine, 2015 - Elsevier
Effective drug delivery to tumors is a barrier to treatment with nanomedicines. Non-invasively
tracking liposome biodistribution and tumor deposition in patients may provide insight into …
tracking liposome biodistribution and tumor deposition in patients may provide insight into …
[HTML][HTML] Brain pharmacology of intrathecal antisense oligonucleotides revealed through multimodal imaging
Intrathecal (IT) delivery and pharmacology of antisense oligonucleotides (ASOs) for the
CNS have been successfully developed to treat spinal muscular atrophy. However, ASO …
CNS have been successfully developed to treat spinal muscular atrophy. However, ASO …
[HTML][HTML] Convective forces increase rostral delivery of intrathecal radiotracers and antisense oligonucleotides in the cynomolgus monkey nervous system
…, L Tayefeh, B DeBrosse-Serra, J Hoppin… - Journal of Translational …, 2020 - Springer
Background The intrathecal (IT) dosing route introduces drugs directly into the CSF to
bypass the blood–brain barrier and gain direct access to the CNS. We evaluated the use of …
bypass the blood–brain barrier and gain direct access to the CNS. We evaluated the use of …
[HTML][HTML] Dynamic dual-isotope molecular imaging elucidates principles for optimizing intrathecal drug delivery
…, KD Orcutt, MD Silva, M Lobo, T Wellman, J Hoppin… - JCI insight, 2016 - ncbi.nlm.nih.gov
The intrathecal (IT) dosing route offers a seemingly obvious solution for delivering drugs
directly to the central nervous system. However, gaps in understanding drug molecule behavior …
directly to the central nervous system. However, gaps in understanding drug molecule behavior …
In vivo radionuclide uptake quantification using a multi-pinhole SPECT system to predict renal function in small animals
…, B Bernard, NU Schramm, JW Hoppin… - European journal of …, 2006 - Springer
Purpose In vivo quantification of radiopharmaceuticals has great potential as a tool in
developing new drugs. We investigated the accuracy of in vivo quantification with multi-pinhole …
developing new drugs. We investigated the accuracy of in vivo quantification with multi-pinhole …
Molecular simulation of receptor occupancy and tumor penetration of an antibody and smaller scaffolds: application to molecular imaging
Purpose Competitive radiolabeled antibody imaging can determine the unlabeled intact
antibody dose that fully blocks target binding but may be confounded by heterogeneous tumor …
antibody dose that fully blocks target binding but may be confounded by heterogeneous tumor …
Dual-Isotope Cryoimaging Quantitative Autoradiography: Investigating Antibody–Drug Conjugate Distribution and Payload Delivery Through Imaging
…, JY Hesterman, K Orcutt, J Hoppin… - Journal of Nuclear …, 2018 - Soc Nuclear Med
In vitro properties of antibody–drug conjugates (ADCs) such as binding, internalization, and
cytotoxicity are often well characterized before in vivo studies. Interpretation of in vivo …
cytotoxicity are often well characterized before in vivo studies. Interpretation of in vivo …
Assessing antibody pharmacokinetics in mice with in vivo imaging
J Hoppin, KD Orcutt, JY Hesterman, MD Silva… - … of Pharmacology and …, 2011 - ASPET
Recent advances in small-animal molecular imaging instrumentation combined with well
characterized antibody-labeling chemistry have enabled detailed in vivo measurements of …
characterized antibody-labeling chemistry have enabled detailed in vivo measurements of …
[HTML][HTML] Longitudinal In Vivo SPECT/CT Imaging Reveals Morphological Changes and Cardiopulmonary Apoptosis in a Rodent Model of Pulmonary Arterial …
…, S Lucas, T Anderson, D Irwin, J Hoppin… - PLoS …, 2012 - journals.plos.org
Pulmonary arterial hypertension (PAH) has a complex pathogenesis involving both heart and
lungs. Animal models can reflect aspects of the human pathology and provide insights into …
lungs. Animal models can reflect aspects of the human pathology and provide insights into …
[HTML][HTML] Regional, kinetic [18F] FDG PET imaging of a unilateral Parkinsonian animal model
…, C Glaus, JY Hesterman, J Hoppin… - American journal of …, 2013 - ncbi.nlm.nih.gov
Positron emission tomography (PET) imaging with the glucose analog 2-deoxy-2-[18 F]
fluoro-D-glucose ([18 F] FDG) has demonstrated clinical utility for the monitoring of brain glucose …
fluoro-D-glucose ([18 F] FDG) has demonstrated clinical utility for the monitoring of brain glucose …