A gradient-loadable 64Cu-chelator for quantifying tumor deposition kinetics of nanoliposomal therapeutics by positron emission tomography

…, E Geretti, J Hesterman, C Harwell, J Hoppin… - … , Biology and Medicine, 2015 - Elsevier
Effective drug delivery to tumors is a barrier to treatment with nanomedicines. Non-invasively
tracking liposome biodistribution and tumor deposition in patients may provide insight into …

[HTML][HTML] Brain pharmacology of intrathecal antisense oligonucleotides revealed through multimodal imaging

…, NJ Albargothy, L Kelly, RO Carare, J Hoppin… - JCI insight, 2019 - ncbi.nlm.nih.gov
Intrathecal (IT) delivery and pharmacology of antisense oligonucleotides (ASOs) for the
CNS have been successfully developed to treat spinal muscular atrophy. However, ASO …

[HTML][HTML] Convective forces increase rostral delivery of intrathecal radiotracers and antisense oligonucleotides in the cynomolgus monkey nervous system

…, L Tayefeh, B DeBrosse-Serra, J Hoppin… - Journal of Translational …, 2020 - Springer
Background The intrathecal (IT) dosing route introduces drugs directly into the CSF to
bypass the blood–brain barrier and gain direct access to the CNS. We evaluated the use of …

[HTML][HTML] Dynamic dual-isotope molecular imaging elucidates principles for optimizing intrathecal drug delivery

…, KD Orcutt, MD Silva, M Lobo, T Wellman, J Hoppin… - JCI insight, 2016 - ncbi.nlm.nih.gov
The intrathecal (IT) dosing route offers a seemingly obvious solution for delivering drugs
directly to the central nervous system. However, gaps in understanding drug molecule behavior …

In vivo radionuclide uptake quantification using a multi-pinhole SPECT system to predict renal function in small animals

…, B Bernard, NU Schramm, JW Hoppin… - European journal of …, 2006 - Springer
Purpose In vivo quantification of radiopharmaceuticals has great potential as a tool in
developing new drugs. We investigated the accuracy of in vivo quantification with multi-pinhole …

Molecular simulation of receptor occupancy and tumor penetration of an antibody and smaller scaffolds: application to molecular imaging

…, AM Wu, MD Silva, C Harwell, J Hoppin… - Molecular imaging and …, 2017 - Springer
Purpose Competitive radiolabeled antibody imaging can determine the unlabeled intact
antibody dose that fully blocks target binding but may be confounded by heterogeneous tumor …

Dual-Isotope Cryoimaging Quantitative Autoradiography: Investigating Antibody–Drug Conjugate Distribution and Payload Delivery Through Imaging

…, JY Hesterman, K Orcutt, J Hoppin… - Journal of Nuclear …, 2018 - Soc Nuclear Med
In vitro properties of antibody–drug conjugates (ADCs) such as binding, internalization, and
cytotoxicity are often well characterized before in vivo studies. Interpretation of in vivo …

Assessing antibody pharmacokinetics in mice with in vivo imaging

J Hoppin, KD Orcutt, JY Hesterman, MD Silva… - … of Pharmacology and …, 2011 - ASPET
Recent advances in small-animal molecular imaging instrumentation combined with well
characterized antibody-labeling chemistry have enabled detailed in vivo measurements of …

[HTML][HTML] Longitudinal In Vivo SPECT/CT Imaging Reveals Morphological Changes and Cardiopulmonary Apoptosis in a Rodent Model of Pulmonary Arterial …

…, S Lucas, T Anderson, D Irwin, J Hoppin… - PLoS …, 2012 - journals.plos.org
Pulmonary arterial hypertension (PAH) has a complex pathogenesis involving both heart and
lungs. Animal models can reflect aspects of the human pathology and provide insights into …

[HTML][HTML] Regional, kinetic [18F] FDG PET imaging of a unilateral Parkinsonian animal model

…, C Glaus, JY Hesterman, J Hoppin… - American journal of …, 2013 - ncbi.nlm.nih.gov
Positron emission tomography (PET) imaging with the glucose analog 2-deoxy-2-[18 F]
fluoro-D-glucose ([18 F] FDG) has demonstrated clinical utility for the monitoring of brain glucose …