Optimization of novel indazoles as highly potent and selective inhibitors of phosphoinositide 3-kinase δ for the treatment of respiratory disease

…, G Vitulli, Y Washio, JN Hamblin - Journal of medicinal …, 2015 - ACS Publications
Optimization of lead compound 1, through extensive use of structure-based design and a
focus on PI3Kδ potency, isoform selectivity, and inhaled PK properties, led to the discovery of …

[HTML][HTML] Host–multi-pathogen warfare: pathogen interactions in co-infected plants

…, FJ Lopez-Ruiz, MR Gibberd, J Hamblin… - Frontiers in plant …, 2017 - frontiersin.org
Studies of plant–pathogen interactions have historically focused on simple models of
infection involving single host-single disease systems. However, plant infections often involve …

Estimation of heritability from varietal trials data

M Singh, S Ceccarelli, J Hamblin - Theoretical and applied genetics, 1993 - Springer
We present the estimation of heritabilities of an observed trait in situations where evaluation
of several pure breeding lines is performed in a trial at a single location and in trials from …

Relationship between barley grain yield measured in low-and high-yielding environments

S Ceccarelli, S Grando, J Hamblin - Euphytica, 1992 - Springer
The paper addresses the general question of identifying the optimum environment for
selection in plant breeding programs for low input agricultural systems. After defining low-yielding …

Breeding common bean for yield in mixtures

J Hamblin, MJO Zimmermann - Plant breeding reviews, 1986 - Wiley Online Library
Mixed cropping of two or more species is the most common form of production in areas where
subsistence agriculture is the norm (Willey and Osiru 1972). Such systems are complex-…

The convergent evolution of annual seed crops in agriculture

CM Donald, J Hamblin - Advances in agronomy, 1983 - Elsevier
Publisher Summary This chapter considers that the yield potential of annual crop species
increase at a faster rate than with empirical selection for yield if suitable ideotypes are identified…

[HTML][HTML] Accelerated generation of selfed pure line plants for gene identification and crop breeding

…, H Wang, Z Lu, Y Wang, D Mullan, J Hamblin… - Frontiers in plant …, 2017 - frontiersin.org
Production of pure lines is an important step in biological studies and breeding of many crop
plants. The major types of pure lines for biological studies and breeding include doubled …

Potent and long-acting dimeric inhibitors of influenza virus neuraminidase are effective at a once-weekly dosing regimen

…, RJ Fenton, D Gower, JN Hamblin… - Antimicrobial agents …, 2004 - Am Soc Microbiol
Dimeric derivatives (compounds 7 to 9) of the influenza virus neuraminidase inhibitor zanamivir
(compound 2), which have linking groups of 14 to 18 atoms in length, are approximately …

Dimeric zanamivir conjugates with various linking groups are potent, long-lasting inhibitors of influenza neuraminidase including H5N1 avian influenza

…, G Foster, D Gower, JN Hamblin… - Journal of medicinal …, 2005 - ACS Publications
The synthesis, antiviral and pharmacokinetic properties of zanamivir (ZMV) dimers 8 and 13
are described. The compounds are highly potent neuraminidase (NA) inhibitors which, …

[HTML][HTML] Safety, pharmacokinetics and dose-response characteristics of GSK2269557, an inhaled PI3Kδ inhibitor under development for the treatment of COPD

A Cahn, JN Hamblin, M Begg, R Wilson… - Pulmonary …, 2017 - Elsevier
Background While current therapies reduce symptoms in chronic obstructive pulmonary
disease (COPD) patients, substantial unmet need remains and novel treatments are highly …