The introduction of the concept of systems biology, enabling the study of living systems from
a holistic perspective based on the profiling of a multitude of biochemical components, …

Metabolomics involves the unbiased quantitative and qualitative analysis of the complete
set of metabolites present in cells, body fluids and tissues (the metabolome). By analyzing …

Medical systems biology has generated widespread interest because of its bold conception
and exciting potential, but the field is still in its infancy. Although there has been tremendous …

Motivation: Datasets resulting from metabolomics or metabolic profiling experiments are
becoming increasingly complex. Such datasets may contain underlying factors, such as time (…

Background Increased dietary cholesterol intake is associated with atherosclerosis.
Atherosclerosis development requires a lipid and an inflammatory component. It is unclear where …

A high-performance liquid chromatography (HPLC) method with on-line coupled ultraviolet (UV),
mass spectrometry (MS) and biochemical detection for acetylcholinesterase (AChE) …

During recent years, phytoestrogens have been receiving an increasing amount of interest,
as several lines of evidence suggest a possible role in preventing a range of diseases, …

Lipidomics is a lipid-targeted metabolomics approach aiming at comprehensive analysis of
lipids in biological systems. Recently, lipid profiling, or so-called lipidomics research, has …

… where 1 is a size N column vector, mT is a size J row vector containing all estimates of j ;
matrices … Jansen JJ, Hoefsloot HCJ, Boelens HFM, J. van der Greef and Smilde AK. Analysis of …

A reversed-phase liquid chromatography-linear ion trap-Fourier transform ion cyclotron
resonance-mass spectrometric method was developed for the profiling of lipids in human and …