This article reviews the present state of the art regarding the toxicokinetics and metabolism
of polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs). The absorption, …

Mechanism-based PK-PD models differ from conventional PK-PD models in that they contain
specific expressions to characterize, in a quantitative manner, processes on the causal …

Glycyrrhizic acid is widely applied as a sweetener in food products and chewing tobacco. In
addition, it is of clinical interest for possible treatment of chronic hepatitis C. In some highly …

… In Vicious Modernism, James de Jongh traces the evolution of the imaginative usage of …
The book concentrates on the aesthetic and cultural force of the idea of Harlem, and de Jongh …

Background and objective A considerable amount of drug use in children is still unlicensed
or off-label. In order to derive rational dosing schemes, the influence of aging on …

Three mode types are proposed for reducing nonlinear dynamical system equations, resulting
from finite element discretizations: tangent modes, modal derivatives, and newly added …

Entrepreneurship has been pointed out as a key contributor to sustained economic growth
and development as it not only creates employment, but increased spending in markets, …

Cooperative adaptive cruise control and platooning are well-known applications in the field
of cooperative automated driving. However, extension toward maneuvering is desired to …

Aims It is well established that there is a wide intra‐ and interindividual variability in dose
requirements for lorazepam and midazolam in intensive care patients. The objective of this …

Effective long-term treatment of Type 2 Diabetes Mellitus (T2DM) implies modification of the
disease processes that cause this progressive disorder. This paper proposes a mechanism-…