By using a strategy based on nucleotide sequence homology, we have cloned a cDNA
encoding a functional serotonin (5-HT) receptor. The deduced amino acid sequence of the 5-HT7 …

Some G-protein-coupled receptors display ‘constitutive activity’, that is, spontaneous activity
in the absence of agonist 1 , 2 , 3 , 4 . This means that a proportion of the receptor …

The detailed distribution of histamine H 3 receptor mRNAs in rat brain was analyzed by in
situ hybridization using a 33 P-labelled riboprobe and was combined for the first time with the …

In cancer, DJ-1/PARK7 acts as an oncogene that drives Akt-mediated cell survival. Although
amplification of DJ-1 has been described in several types of tumors, the mechanistic basis …

Starting from the sequence of the human histamine H 3 receptor (hH 3 R) cDNA, we have
cloned the corresponding rat cDNA. Whereas the two deduced proteins show 93.5% overall …

Constitutive activity of the recombinant and native rat and human H 3 receptors (H 3 Rs) was
studied using H 3 R‐mediated [ 35 S]GTPγ[S] binding and [ 3 H]‐arachidonic acid release. …

G protein-coupled receptors (GPCRs) are allosteric proteins that adopt inactive (R) and active
(R * ) conformations in equilibrium. R * is promoted by agonists or occurs spontaneously, …

Using a bioinformatic approach, we identified a TP53INP1-related gene encoding a protein
with 30% identity with tumor protein 53-induced nuclear protein 1 (TP53INP1), which was …

Autoradiographic studies of the distribution of the histamine H 2 receptor and its messenger
RNAs were performed on serial frontal and a few sagittal sections of guinea-pig brain using [ …

A cDNA encoding a guinea pig histamine H 1 receptor was stably expressed in Chinese
hamster ovary (CHO) cells. In one resulting clone, named CHO(H 1 ), the H 1 receptor was …