Aims The mechanisms involved in hypoxic pulmonary vasoconstriction (HPV) are not yet
fully defined. The aim of the study was to determine the role of protein kinase C ζ (PKCζ) and …

Quercetin is a dietary flavonoid which exerts vasodilator, antiplatelet and antiproliferative
effects and reduces blood pressure, oxidative status and end-organ damage in humans and …

Regulation of breathing is critical to our capacity to accommodate deficits in oxygen availability
and demand during, for example, sleep and ascent to altitude. It is generally accepted …

Recent data suggest that diabetes is a risk factor for pulmonary hypertension. The aim of the
present study was to analyze whether diabetes induces endothelial dysfunction in …

Although type 1 and type 2 diabetes are strongly associated with systemic cardiovascular
morbidity, the relationship with pulmonary vascular disease had been almost disregarded until …

… Analysis of genetically manipulated mice by Moral-Sanz et al. showed that hypoxic
pulmonary vasoconstriction under mild hypoxia required the α1 subunit of AMPK, which was …

… Javier Moral-Sanz … Javier Moral-Sanz … Remarkably, the pulmonary vasodilation induced
by riociguat was attenuated by XE991 (Figure 9j), indicating that activation of K v 7 channels …

The molecular mechanisms underlying hypoxic pulmonary vasoconstriction (HPV) are not
yet properly understood. Mitochondrial electron transport chain (ETC) and NADPH oxidase …

Aims: A variety of vessels, such as resistance pulmonary arteries (PA) and fetoplacental arteries
and the ductus arteriosus (DA) are specialized in sensing and responding to changes in …

… ‐activated protein kinase inhibits Kv1.5 channel currents of pulmonary arterial myocytes in
response to hypoxia and inhibition of mitochondrial oxidative phosphorylation - Moral‐Sanz - …