BACKGROUND Bisphosphonates currently are the most important class of antiresorptive
agents used in the treatment of metabolic bone diseases, including tumor‐associated …

The central feature of Paget’s disease is the osteoclast, because the pathological characteristics
of the disease (such as bone pain, fractures, and skeletal deformities) are the result of …

Bisphosphonates (BP) are a class of calcium-binding drug used to prevent bone resorption
in skeletal disorders such as osteoporosis and metastatic bone disease. They act by …

Human peripheral Vγ9Vδ2 T cells are activated by phosphorylated metabolites (phosphoagonists
[PAg]) of the mammalian mevalonate or the microbial desoxyxylulose-phosphate …

Introduction The immune system plays a major role in cancer progression. In solid tumors, 5-40
% of the tumor mass consists of tumor-associated macrophages (TAMs) and there is …

Bisphosphonates are currently the most important class of antiresorptive drugs used for the
treatment of diseases with excess bone resorption. On the basis of their molecular …

… J This work was partly presented in the abstracts of poster presentations at the Fourth
International Prediction of Percutaneous Penetration Conference (held in La Grande Motte, France…

Background— Inflammation is critical to vascular repair after mechanical injury. Excessive
inflammation enhances neointimal formation and restenosis. We examined whether transient …

The nitrogen-containing bisphosphonate zoledronic acid (ZOL), a potent inhibitor of farnesyl
pyrophosphate synthase, blocks the mevalonate pathway, leading to intracellular …

In spite of good research in drug delivery, bone targeting remains largely unexplored. Even
some of the bone diseases are seldom cured just because of poor distribution of drug at the …