… Experiments have also indicated, using radio C-14 label I-naphthylamine, that there are an
additional six metabolites that remain unidentified (JL Radomski, unpub lished observation). …

This review addresses itself to the chemical and biological characteristics of synthetic food
dyes that relate to their safety evaluation, with particular reference to those dyes permitted for …

Dimethylnitrosamine, a powerful carcinogen, is produced in the urine of patients with urinary
tract infections of Proteus mirabilis and Escherichia coli when nitrite is present. Treatment …

When beginning a discussion of food colors it is customary to point out that man has been
artificially coloring his food since ancient times and that color is an important characteristic of …

The metabolism of water soluble azo dyes FD-and-C-Red-No-4, FD-and-C-Red-No-4 and
FD-and-C-Yellow-No-6 was studied in rats. Dye was administered to the rats orally by …

Repeated installation of N-hydroxy-2 naphthylamine into dog bladders produced tumors of
this organ. There is a correlation of degree of carcinogenicity of 1-naphthylamine, 2-…

Glucuronide conjugates of carcinogenic N-hydroxy metabolites of the primary aromatic
amines, 4-aminobiphenyl (4-ABP), 2-naphthylamine (2-NA), and 1-naphthylamine (1-NA) were …

A method suitable for the analysis of nitrate in human urine was developed. Normal urinary
concentrations of nitrate in urine of human volunteers in Dade County, Florida, where the …

Organochlorine pesticide concentrations have been determined at autopsy in the fat and
liver of 271 patients previously exhibiting various pathological states of the liver, brain and …

N-Hydroxy-2-naphthylamine produced bladder tumors in three of four dogs when administered
over a period of 30 months (dogs were sacrificed 15 months later) in dimethyl sulfoxide …