Most drugs are carried from their sites of absorption to their sites of action and elimination by
the circulating blood. Some drugs are simply dissolved in serum water, but many others are …

THE intensity of the therapeutic and toxic effects of most pharmacologic agents depends on
their concentration at the sites of action. The time course of this concentration is determined …

The last few years have seen significant progress toward an understanding of the interval-strength
relationship of heart muscle, particularly in regard to the relation of the various …

… HALL J : Colistin: analysis of new antibiotic in 44 cases of systemic gram-negative bacterial
… and HINES J : Neurotoxic and nephrotoxic effects of colistin in patients with renal disease. …

Of 13,349 hospitalized medical patients monitored in a drug surveillance program, 788 (5.9%)
received spironolactone during one or more admissions. Adverse reactions were …

The relationship of dosage to plasma concentration of procainamide varied greatly among
186 patients. This variation resulted from individual differences in completeness of absorption…

The highly selective, enzyme-activated, irreversible inhibitor of L-ornithine decarboxylase,
DL-α-difluoromethylornithine, suppresses the increase in uterine L-ornithine decarboxylase …

Creatinine excretion was studied in eight healthy males who collected 54 to 97 24-hour urine
specimens. Significant differences among subjects in mean creatinine excretion were only …

The extent of drug binding to plasma protein does not influence the concentration of
unbound drug in plasma at steady state but does influence the interpretation of total drug …

DRUG dosages needed for optimal therapeutic effects differ widely among patients. The "usual
dose" of most potent drugs accomplishes little in some persons, causes serious toxicity in …