A series of azole antifungal agents featuring a quinazolinone nucleus have been subjected
to studies of structure−activity relationships. In general, these compounds displayed higher …

The synthesis and pharmacological activity of a series of bicyclic pyrazolo[1,5-a]pyrimidines
as potent and selective cyclooxygenase-2 (COX-2) inhibitors are described. The new …

Background: Androgen receptor (AR) gene mutations are the most frequent cause of 46,XY
disorders of sex development (DSD) and are associated with a variety of phenotypes, …

Rupatadine (UR-12592, 8-chloro-6,11-dihydro-11-[1-[(5-methyl3-pyridinyl)methyl]-4-piperidinylidene]-5H-benzo[5,6]cyclohepta[1,2b]pyridine)
is a novel compound that inhibits both …

The synthesis and pharmacological activity of a new series of 5-(biphenyl-4-ylmethyl)pyrazoles
as potent angiotensin II antagonists both in vitro (binding of [ 3 H]AII) and in vivo (iv, …

Agents known to inphorylation of specific endogenous proteins in intact synaptosomes from
rat brain. Synaptosome preparations, preincubated in vitro with 32Pi, incorporated 32P into …

Sodium fluoride-induced adenyl cyclase activity of rat and rabbit cerebral cortex homogenates
is inhibited by a wide range of concentrations of lithium. Lithium also inhibits NE-induced …

… [J. A. Beavo, NL Rogers, OB Crofford, JG Hardman, EW Sutherland, EV Newman, Mol.…
We are grateful to J. P. Perkins for suggesting the use of 3-isobutyl-1-methylxanthine as the …

A series of 92 azole antifungals containing an amido alcohol unit was synthesized. The nature
and substitution of the amide portion was systematically modified in search of improved …

The regulation of the state of phosphorylation of two specific neuronal proteins, designated
protein Ia and protein 1b, has been studied in slices of rat cerebral cortex incubated in vitro. …