An overview of the preclinical aspects of topiramate: pharmacology, pharmacokinetics, and mechanism of action
RP Shank, JF Gardocki, AJ Streeter, BE Maryanoff - Epilepsia, 2000 - Wiley Online Library
In this overview, we discuss the discovery and development of topiramate (TPM) as an
anticonvulsant, including notable aspects of its chemical, biologic, and pharmacokinetic properties…
anticonvulsant, including notable aspects of its chemical, biologic, and pharmacokinetic properties…
Topiramate: preclinical evaluation of a structurally novel anticonvulsant
RP Shank, JF Gardocki, JL Vaught, CB Davis… - …, 1994 - Wiley Online Library
… Preliminary reports on its biologic profile were presented by Gardocki et al. (1986), who
discovered its anticonvulsant activity, and by Shank et al. (1991) and Vaught et al. …
discovered its anticonvulsant activity, and by Shank et al. (1991) and Vaught et al. …
Anticonvulsant O-alkyl sulfamates. 2, 3: 4, 5-Bis-O-(1-methylethylidene)-. beta.-D-fructopyranose sulfamate and related compounds
BE Maryanoff, SO Nortey, JF Gardocki… - Journal of medicinal …, 1987 - ACS Publications
Novel sugar sulfamate 1 (McN-4853, topiramate) has been found to exhibit potent anticonvulsant
activity analogous to that of phenytoin. In the maximal electroshock seizure test, orally …
activity analogous to that of phenytoin. In the maximal electroshock seizure test, orally …
Pyrroloisoquinoline antidepressants. 2. In-depth exploration of structure-activity relationships
BE Maryanoff, DF McComsey, JF Gardocki… - Journal of medicinal …, 1987 - ACS Publications
A series of pyrrolo [2, lo] isoquinolines, and related compounds, were examined for
antidepressant-like activity, by virtue of their antagonism of tetrabenazine-inducedptosis and sedation…
antidepressant-like activity, by virtue of their antagonism of tetrabenazine-inducedptosis and sedation…
Changes in interhemispheric amplitude relationships in the EEG during sleep
L Goldstein, NW Stoltzfus, JF Gardocki - Physiology & Behavior, 1972 - Elsevier
The method of integrative EEG analysis has been used to establish ratios between amplitudes
in the left and right cerebral hemispheres during spontaneous sleep in man, in cats and in …
in the left and right cerebral hemispheres during spontaneous sleep in man, in cats and in …
A study of some of the pharmacologic actions of fentanyl citrate
JF Gardocki, J Yelnosky - Toxicology and applied pharmacology, 1964 - Elsevier
Fentanyl citrate is an analgesic that is particularly well suited for use in anesthesia because
of its (1) high potency, (2) rapid onset and short duration of action, (3) absence of emetic …
of its (1) high potency, (2) rapid onset and short duration of action, (3) absence of emetic …
Potential anxiolytic agents. Pyrido [1, 2-a] benzimidazoles: A new structural class of ligands for the benzodiazepine binding site on GABA-A receptors
…, B Dubinsky, RJJ Taylor, JF Gardocki - Journal of medicinal …, 1995 - ACS Publications
Receptors for y-aminobutyric acid of the “A” variety (GABA-A receptors), the most abundant
inhibitory receptors in mammalian brain, are structurally consti-tuted as macromolecular …
inhibitory receptors in mammalian brain, are structurally consti-tuted as macromolecular …
Pyrroloisoquinoline antidepressants. Potent, enantioselective inhibition of tetrabenazine-induced ptosis and neuronal uptake of norepinephrine, dopamine, and …
…, MJ Costanzo, PE Setler, JF Gardocki… - Journal of medicinal …, 1984 - ACS Publications
Sir: Inhibitors of brain norepinephrine (NE) and/or sero-tonin (5-HT) uptake increase the
concentration of biogenic amine neurotransmitters in synaptic regions of the brain, a property …
concentration of biogenic amine neurotransmitters in synaptic regions of the brain, a property …
2-Pyrrolidinylideneureas, a new class of central nervous system agents
CR Rasmussen, JF Gardocki, JN Plampin… - Journal of Medicinal …, 1978 - ACS Publications
thiepin-2-acetate (2.2 g, 7.75 mmol) in iert-butyl alcohol (15 mL) containing potassium tert-butoxide
(0.87 g, 7.77 mmol) and diethyl carbonate (1.0 g, 8.5 mmol) was boiled under reflux …
(0.87 g, 7.77 mmol) and diethyl carbonate (1.0 g, 8.5 mmol) was boiled under reflux …
A study of some of the pharmacologic actions of fentanyl citrate and droperidol
J Yelnosky, JF Gardocki - Toxicology and applied pharmacology, 1964 - Elsevier
Innovan ® , a mixture of fentanyl citrate and droperidol, possesses greater analgesic activity
than is provided by fentanyl citrate alone. As the increase in analgesia is not paralleled by …
than is provided by fentanyl citrate alone. As the increase in analgesia is not paralleled by …