Cloning, sequencing, and molecular analysis of the dnaK locus from Bacillus subtilis

M Wetzstein, U Völker, J Dedio, S Löbau… - Journal of …, 1992 - Am Soc Microbiol
By using an internal part of the dnaK gene from Bacillus megaterium as a probe, a 5.2-kb
HindIII fragment of chromosomal DNA of Bacillus subtilis was cloned. Downstream sequences …

NOSTRIN: a protein modulating nitric oxide release and subcellular distribution of endothelial nitric oxide synthase

K Zimmermann, N Opitz, J Dedio… - Proceedings of the …, 2002 - National Acad Sciences
Activity and localization of endothelial nitric oxide synthase (eNOS) is regulated in a
remarkably complex fashion, yet the complex molecular machinery mastering stimulus-induced …

[HTML][HTML] Isolation and characterization of the kininogen-binding protein p33 from endothelial cells: identity with the gC1q receptor

H Herwald, J Dedio, R Kellner, M Loos… - Journal of Biological …, 1996 - ASBMB
Kininogens, the precursor proteins of the vasoactive kinins, bind specifically, reversibly, and
saturably to platelets, neutrophils, and endothelial cells. Two domains of the kininogens …

The multiligand-binding protein gC1qR, putative C1q receptor, is a mitochondrial protein

J Dedio, W Jahnen-Dechent, M Bachmann… - The Journal of …, 1998 - journals.aai.org
A protein of 33 kDa (p33) that tightly binds to the globular domains of the first complement
component, C1q, is thought to serve as the major C1q receptor (gC1qR) on B cells, neutrophils…

NOSIP, a novel modulator of endothelial nitric oxide synthase activity

J DEDIO, P König, P Wohlfart… - The FASEB …, 2001 - Wiley Online Library
… In fact, we have found a weak though significant interaction between the nNOS oxygenase
domain and NOSIP in the yeast two-hybrid system (J. Dedio, unpublished observations). …

[HTML][HTML] Blockade of cannabinoid CB1 receptors improves renal function, metabolic profile, and increased survival of obese Zucker rats

…, F Pierre, L Gouraud, I Barbosa, J Dedio… - Kidney international, 2007 - Elsevier
Obesity is a major risk factor in the development of chronic renal failure. Rimonabant, a
cannabinoid CB1 receptor antagonist, improves body weight and metabolic disorders; however, …

Interleukin-1β stimulates acute phase response and C-reactive protein synthesis by inducing an NFκB-and C/EBPβ-dependent autocrine interleukin-6 loop

…, J Kamenz, K Veit, V Hombach, J Dedio… - Molecular …, 2008 - Elsevier
Cytokines interleukin-1β (IL-1β) and interleukin-6 (IL-6) are involved in acute phase response
(APR). C-reactive protein (CRP), the prototype acute phase protein, may represent an …

Integrated synthesis and testing of substituted xanthine based DPP4 inhibitors: application to drug discovery

W Czechtizky, J Dedio, B Desai, K Dixon… - ACS Medicinal …, 2013 - ACS Publications
A novel integrated discovery platform has been used to synthesize and biologically assay a
series of xanthine-derived dipeptidyl peptidase 4 (DPP4) antagonists. Design, synthesis, …

[HTML][HTML] Protein kinase C μ is regulated by the multifunctional chaperon protein p32

P Storz, A Hausser, G Link, J Dedio… - Journal of Biological …, 2000 - ASBMB
We identified the multifunctional chaperon protein p32 as a protein kinase C (PKC)-binding
protein interacting with PKCα, PKCζ, PKCδ, and PKCμ. We have analyzed the interaction of …

[HTML][HTML] High molecular weight kininogen utilizes heparan sulfate proteoglycans for accumulation on endothelial cells

T Renné, J Dedio, G David, W Müller-Esterl - Journal of Biological …, 2000 - ASBMB
Kininogens, the high molecular weight precursor of vasoactive kinins, bind to a wide variety
of cells in a specific, reversible, and saturable manner. The cell docking sites have been …