The objective of this study was to test whether a glycosaminoglycan component of the
surface glycocalyx layer is a fluid shear stress sensor on endothelial cells (ECs). Because …

To increase our understanding of important subject characteristics and design variables
affecting the performance of oral moxifloxacin in thorough QT studies, population …

Na + /H + exchanger isoform-1 (NHE1), the ubiquitous form of the Na + /H + exchanger, has
increased activity in hypertensive patients and in animal models of hypertension. …

5-Hydroxytryptamine (5-HT) activates the extracellular signal-regulated kinase (Erk) mitogen-activated
protein kinases (MAPKs) in the vasculature, resulting in contraction. The …

Vascular 5-Hydroxytryptamine 2A (5-HT 2A ) receptor signaling and contraction has been
associated with the activation of L-type calcium channels, phospholipase C (PLC) and, as we …

We have tested the hypothesis that growth factor signaling pathways are augmented in
hypertension, a disease associated with vascular smooth muscle cell growth. Thoracic aorta was …

Cytidine analogues such as cytosine arabinoside, gemcitabine, decitabine, 5-azacytidine, 5-fluoro-2′-deoxycytidine
and 5-chloro-2′-deoxycytidine undergo rapid catabolism by …

A nonlinear model predictive control (NMPC) algorithm was developed to dose the
chemotherapeutic agent tamoxifen based on a novel saturating-rate, cell-cycle model (SCM). Using …

Angiotensin II (Ang II) is a potent pressor hormone, a stimulus for vascular smooth muscle
hypertrophy and an activator of multiple tyrosine kinases. The physiological effects of Ang II …

The objective of this study was to develop a pharmacokinetic–pharmacodynamic (PK-PD)
model of the static allodynia response to pregabalin with and without sildenafil in a chronic …