User profiles for J. W. Jonker
Johan W. JonkerProfessor, University Medical Center Groningen Verified email at umcg.nl Cited by 14328 |
Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview
AH Schinkel, JW Jonker - Advanced drug delivery reviews, 2012 - Elsevier
Active drug efflux transporters of the ATP binding cassette (ABC)-containing family of proteins
have a major impact on the pharmacological behavior of most of the drugs in use today. …
have a major impact on the pharmacological behavior of most of the drugs in use today. …
Abnormal liver function tests in patients with COVID‐19: relevance and potential pathogenesis
…, A Fantin, F Farinati, R Fiorotto, JW Jonker… - Hepatology, 2020 - journals.lww.com
Lipopolysaccharide Reverses Hepatic Stellate Cell Activation... : Hepatology Lipopolysaccharide
Reverses Hepatic Stellate Cell Activation Through Modulation of cMyb, Small Mothers Against …
Reverses Hepatic Stellate Cell Activation Through Modulation of cMyb, Small Mothers Against …
Pharmacological and physiological functions of the polyspecific organic cation transporters: OCT1, 2, and 3 (SLC22A1-3)
JW Jonker, AH Schinkel - Journal of Pharmacology and Experimental …, 2004 - ASPET
For the elimination of environmental toxins and metabolic waste products, the body is
equipped with a range of broad-specificity transporters that are generally present in the liver, …
equipped with a range of broad-specificity transporters that are generally present in the liver, …
Role of breast cancer resistance protein in the bioavailability and fetal penetration of topotecan
JW Jonker, JW Smit, RF Brinkhuis… - Journal of the …, 2000 - academic.oup.com
Background and Methods: Breast cancer resistance protein (BCRP/MXR/ABCP) is a
multidrug-resistance protein that is a member of the adenosine triphosphate-binding cassette family …
multidrug-resistance protein that is a member of the adenosine triphosphate-binding cassette family …
The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria
JW Jonker, M Buitelaar, E Wagenaar… - Proceedings of the …, 2002 - National Acad Sciences
The breast cancer resistance protein (BCRP/ABCG2) is a member of the ATP-binding cassette
family of drug transporters and confers resistance to various anticancer drugs. We show …
family of drug transporters and confers resistance to various anticancer drugs. We show …
Short-chain fatty acids protect against high-fat diet–induced obesity via a PPARγ-dependent switch from lipogenesis to fat oxidation
…, R Havinga, TH van Dijk, MH Oosterveer, JW Jonker… - Diabetes, 2015 - Am Diabetes Assoc
Short-chain fatty acids (SCFAs) are the main products of dietary fiber fermentation and are
believed to drive the fiber-related prevention of the metabolic syndrome. Here we show that …
believed to drive the fiber-related prevention of the metabolic syndrome. Here we show that …
Cryptochromes mediate rhythmic repression of the glucocorticoid receptor
…, RT Yu, GD Barish, NH Uhlenhaut, JW Jonker… - Nature, 2011 - nature.com
Mammalian metabolism is highly circadian and major hormonal circuits involving nuclear
hormone receptors display interlinked diurnal cycling 1 , 2 . However, mechanisms that …
hormone receptors display interlinked diurnal cycling 1 , 2 . However, mechanisms that …
Involvement of organic cation transporter 1 in hepatic and intestinal distribution of metformin
Metformin, a biguanide, is widely used as an oral hypoglycemic agent for the treatment of type
2 diabetes mellitus. The purpose of the present study was to investigate the role of organic …
2 diabetes mellitus. The purpose of the present study was to investigate the role of organic …
The breast cancer resistance protein BCRP (ABCG2) concentrates drugs and carcinogenic xenotoxins into milk
Contamination of milk with drugs, pesticides and other xenotoxins can pose a major health
risk to breast-fed infants and dairy consumers. Here we show that the multidrug transporter …
risk to breast-fed infants and dairy consumers. Here we show that the multidrug transporter …
[HTML][HTML] ERRγ directs and maintains the transition to oxidative metabolism in the postnatal heart
At birth, the heart undergoes a critical metabolic switch from a predominant dependence on
carbohydrates during fetal life to a greater dependence on postnatal oxidative metabolism. …
carbohydrates during fetal life to a greater dependence on postnatal oxidative metabolism. …