User profiles for J. W. Jonker

Johan W. Jonker

Professor, University Medical Center Groningen
Verified email at umcg.nl
Cited by 14328

Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview

AH Schinkel, JW Jonker - Advanced drug delivery reviews, 2012 - Elsevier
Active drug efflux transporters of the ATP binding cassette (ABC)-containing family of proteins
have a major impact on the pharmacological behavior of most of the drugs in use today. …

Abnormal liver function tests in patients with COVID‐19: relevance and potential pathogenesis

…, A Fantin, F Farinati, R Fiorotto, JW Jonker… - Hepatology, 2020 - journals.lww.com
Lipopolysaccharide Reverses Hepatic Stellate Cell Activation... : Hepatology Lipopolysaccharide
Reverses Hepatic Stellate Cell Activation Through Modulation of cMyb, Small Mothers Against …

Pharmacological and physiological functions of the polyspecific organic cation transporters: OCT1, 2, and 3 (SLC22A1-3)

JW Jonker, AH Schinkel - Journal of Pharmacology and Experimental …, 2004 - ASPET
For the elimination of environmental toxins and metabolic waste products, the body is
equipped with a range of broad-specificity transporters that are generally present in the liver, …

Role of breast cancer resistance protein in the bioavailability and fetal penetration of topotecan

JW Jonker, JW Smit, RF Brinkhuis… - Journal of the …, 2000 - academic.oup.com
Background and Methods: Breast cancer resistance protein (BCRP/MXR/ABCP) is a
multidrug-resistance protein that is a member of the adenosine triphosphate-binding cassette family …

The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria

JW Jonker, M Buitelaar, E Wagenaar… - Proceedings of the …, 2002 - National Acad Sciences
The breast cancer resistance protein (BCRP/ABCG2) is a member of the ATP-binding cassette
family of drug transporters and confers resistance to various anticancer drugs. We show …

Short-chain fatty acids protect against high-fat diet–induced obesity via a PPARγ-dependent switch from lipogenesis to fat oxidation

…, R Havinga, TH van Dijk, MH Oosterveer, JW Jonker… - Diabetes, 2015 - Am Diabetes Assoc
Short-chain fatty acids (SCFAs) are the main products of dietary fiber fermentation and are
believed to drive the fiber-related prevention of the metabolic syndrome. Here we show that …

Cryptochromes mediate rhythmic repression of the glucocorticoid receptor

…, RT Yu, GD Barish, NH Uhlenhaut, JW Jonker… - Nature, 2011 - nature.com
Mammalian metabolism is highly circadian and major hormonal circuits involving nuclear
hormone receptors display interlinked diurnal cycling 1 , 2 . However, mechanisms that …

Involvement of organic cation transporter 1 in hepatic and intestinal distribution of metformin

DS Wang, JW Jonker, Y Kato, H Kusuhara… - … of Pharmacology and …, 2002 - ASPET
Metformin, a biguanide, is widely used as an oral hypoglycemic agent for the treatment of type
2 diabetes mellitus. The purpose of the present study was to investigate the role of organic …

The breast cancer resistance protein BCRP (ABCG2) concentrates drugs and carcinogenic xenotoxins into milk

JW Jonker, G Merino, S Musters, AE van Herwaarden… - Nature medicine, 2005 - nature.com
Contamination of milk with drugs, pesticides and other xenotoxins can pose a major health
risk to breast-fed infants and dairy consumers. Here we show that the multidrug transporter …

[HTML][HTML] ERRγ directs and maintains the transition to oxidative metabolism in the postnatal heart

…, W Xie, W He, CR Dufour, M Downes, JW Jonker… - Cell metabolism, 2007 - cell.com
At birth, the heart undergoes a critical metabolic switch from a predominant dependence on
carbohydrates during fetal life to a greater dependence on postnatal oxidative metabolism. …