Resveratrol, a polyphenol found in red wine, peanuts, soy beans, and pomegranates, possesses
a wide range of biological effects. Since resveratrol's properties seem ideal for treating …

A novel monoclonal antibody has been developed that reacts strongly with human prostatic
cancer, especially tumors of high grade. This antibody (7E11C-5) is currently in Phase 3 …

Pathways that regulate mitochondrial biogenesis are potential therapeutic targets for the
amelioration of endothelial dysfunction and vascular disease. Resveratrol was shown to impact …

The production of hyperglycemia-induced mitochondrial reactive oxygen species (mtROS)
is a key event in the development of diabetic complications. Because resveratrol, a naturally …

Endothelial dysfunction, oxidative stress and inflammation are associated with vascular aging
and promote the development of cardiovascular disease. Caloric restriction (CR) mitigates …

Oxidative stress is pathogenic in neurological diseases, including stroke. The identity of
oxidative stress–inducible transcription factors and their role in propagating the death cascade …

Objectives N‐acetylcysteine (NAC) is a clinically approved thiol‐containing redox modulatory
compound currently in trials for many neurological and psychiatric disorders. Although …

Aging promotes oxidative stress in vascular endothelial and smooth muscle cells, which
contribute to the development of cardiovascular diseases. NF-E2–related factor 2 (Nrf2) is a …

Proliferation of pulmonary arterial smooth muscle cells, endothelial dysfunction, oxidative
stress, and inflammation promotes the development of pulmonary hypertension. Resveratrol is …

Oxidative stress is implicated in the pathogenesis of ischemia/reperfusion injury. Recently,
we demonstrated that activation of CD36, a class B scavenger receptor, mediates free radical …