Back-propagation artificial neural networks (ANNs) were trained on a dataset of 42 molecules
with quantitative IC 50 values to model structure–activity relationships of mono- and bis-…

A series of bis-nicotinium, bis-pyridinium, bis-picolinium, bis-quinolinium and bis-isoquinolinium
compounds was evaluated for their binding affinity at nicotinic acetylcholine receptors (…

A series of alkyl disulfides has been shown to be reduced by tributyl phosphine at room
temperature. The resulting thiols were then acylated in the same pot and isolated in good yields. …

Nn-Alkylpicolinium and N,N′-alkyl-bis-picolinium analogues were assessed in nicotinic
receptor (nAChR) assays. The most potent and subtype-selective analogue, N,N′-dodecyl-bis-…

The current study evaluated a new series of N,N′-alkane-diyl-bis-3-picolinium (bAPi) analogs
with C 6 –C 12 methylene linkers as nicotinic acetylcholine receptor (nAChR) antagonists…

The current study demonstrates thatN-n-alkylnicotinium analogs with increasing n-alkyl
chain lengths from 1 to 12 carbons have varying affinity (K i = 90 nM–20 μM) for S-(−)-[ 3 H]…

Neuronal nicotinic acetylcholine receptors (nAChRs) belong to a superfamily of ligand-gated
ion channel receptors and are distributed extensively throughout the central and peripheral …

Here we describe a one-pot synthesis of a series of β-substituted amines as single enantiomers
from an initial regioisomeric mixture of styrene oxide ring-opening products. We also …

The structure of the S(−)-nicotine molecule was modified via N-n-alkylation of the pyridine-N
atom to afford a series ofN-n-alkylnicotinium iodide salts with carbon chain lengths varying …

Nn-Alkylation of nicotine converts it from an agonist into an antagonist at neuronal nicotinic
acetylcholine receptor subtypes mediating nicotine-evoked dopamine release. …