Lysophosphatidic acid (LPA) is a bioactive phospholipid controlling numerous cellular
responses through the activation of specific G-protein coupled transmembrane receptors. LPA is …

The results presented herein demonstrate that apelin is expressed and secreted by both
human and mouse adipocytes. Apelin mRNA levels in isolated adipocytes are close to other …

The development of fibrosis involves a multitude of events and molecules. Until now the
majority of these molecules were found to be proteins or peptides. But recent data show …

… This is also observed after chronic treatment with Ki16425 (Rancoule and Saulnier-Blache,
personal results). Consequently, adipose tissue from FATX-KO mice and Ki16425-treated …

Autotaxin (ATX), or nucleotide pyrophosphatase-phosphodiesterase 2, is a secreted
lysophospholipase D that promotes cell migration, metastasis, and angiogenesis. ATX generates …

We have recently identified apelin as a novel adipokine up‐regulated by insulin and obesity.
Since obesity and insulin resistance are associated with chronically elevated levels of both …

The role of lysophosphatidic acid (LPA) in cancer is poorly understood. Here we provide
evidence for a role of LPA in the progression of breast cancer bone metastases. LPA receptors …

… Jean Sébastien Saulnier-Blache Jean Sébastien Saulnier-Blache … Saulnier-Blache JS …

Oxidatively modified low-density lipoprotein (oxLDL) plays a key role in the initiation of
atherosclerosis by increasing monocyte adhesion. The mechanism that is responsible for the …

Autotaxin (ATX) is a secreted lysophospholipase D that generates the lipid mediator
lysophosphatidic acid (LPA). ATX is secreted by adipose tissue and its expression is enhanced in …