There is a constant high demand for energy to sustain the continuous contractile activity of the
heart, which is met primarily by the β-oxidation of long-chain fatty acids. The control of fatty …

Dramatic maturational changes occur in cardiac energy metabolism during cardiac
development, differentiation, and postnatal growth. These changes in energy metabolism have …

Cardiac ischemia and its consequences including heart failure, which itself has emerged as
the leading cause of morbidity and mortality in developed countries are accompanied by …

OBJECTIVE It has been proposed that skeletal muscle insulin resistance arises from the
accumulation of intramyocellular lipid metabolites that impede insulin signaling, including …

Background— Cardiac hypertrophy is accompanied by significant alterations in energy
metabolism. Whether these changes in energy metabolism precede and contribute to the …

Aims Lysine acetylation is a novel post-translational pathway that regulates the activities of
enzymes involved in both fatty acid and glucose metabolism. We examined whether lysine …

Aims During reperfusion of the ischaemic myocardium, fatty acid oxidation rates quickly recover,
while glucose oxidation rates remain depressed. Direct stimulation of glucose oxidation …

Impaired skeletal muscle fatty acid oxidation has been suggested to contribute to insulin
resistance and glucose intolerance. However, increasing muscle fatty acid oxidation may cause …

OBJECTIVE Whereas an impaired ability to oxidize fatty acids is thought to contribute to
intracellular lipid accumulation, insulin resistance, and cardiac dysfunction, high rates of fatty …

Aims To determine whether post-infarction LV dysfunction is due to low energy availability
or inefficient energy utilization, we compared energy metabolism in normal and failing hearts. …