Epigenetics, the modification of chromatin without changing the DNA sequence itself,
determines whether a gene is expressed, and how much of a gene is expressed. Methylation of …

Histone deacetylase inhibitors (HDACi) are promising anti-cancer agents, however, their
mechanisms of action remain unclear. In acute myeloid leukemia (AML) cells, HDACi have …

Transcriptional activation by nuclear hormone receptors is well characterized, but their
cooperation with other signaling pathways to activate transcription remains poorly understood. …

Diffuse large B-cell lymphoma (DLBCL) accounts for 40% of non-Hodgkin lymphoma, and
30% to 40% of patients will succumb to relapsed/refractory disease (rrDLBCL). Patients with …

Histone deacetylase inhibitors (HDACi) have modest objective response rates ranging from
5.5% to 49%[1–5] as single agents. Furthermore, HDACi exert their antitumor effects in …

Histone deacetylase inhibitors (HDACi) have shown promising activity against hematological
malignancies in clinical trials and have led to the approval of vorinostat for the treatment of …

To separate causal effects of histone acetylation on chromatin accessibility and transcriptional
output, we used integrated epigenomic and transcriptomic analyses following acute …

This study examined the relationship between objectively measured nocturnal hot flashes
and objectively measured sleep in breast cancer survivors with insomnia. Twenty-four women …

Multiple myeloma (MM) is a plasma cell neoplasm associated with a broad variety of
genetic lesions. In spite of this genetic heterogeneity, MMs share a characteristic malignant …

This review examines the current state of knowledge regarding children’s biological stress
response during the transition from preschool to compulsory formal schooling, focusing on …