Discovery of Potent 2-Aryl-6,7-dihydro-5H-pyrrolo[1,2-a]imidazoles as WDR5-WIN-Site Inhibitors Using Fragment-Based Methods and Structure-Based Design
…, Q Sun, S Wang, DM Camper, JP Yuh… - Journal of medicinal …, 2018 - ACS Publications
WDR5 is a chromatin-regulatory scaffold protein overexpressed in various cancers and a
potential epigenetic drug target for the treatment of mixed-lineage leukemia. Here, we describe …
potential epigenetic drug target for the treatment of mixed-lineage leukemia. Here, we describe …
Discovery and optimization of salicylic acid-derived sulfonamide inhibitors of the WD repeat-containing protein 5–MYC protein–protein interaction
…, JG Shaw, JE Howes, J Sai, JP Yuh… - Journal of medicinal …, 2019 - ACS Publications
The treatment of tumors driven by overexpression or amplification of MYC oncogenes
remains a significant challenge in drug discovery. Here, we present a new strategy toward the …
remains a significant challenge in drug discovery. Here, we present a new strategy toward the …
VU0477573: partial negative allosteric modulator of the subtype 5 metabotropic glutamate receptor with in vivo efficacy
HH Nickols, JP Yuh, KJ Gregory, RD Morrison… - Journal of pharmacology …, 2016 - ASPET
Negative allosteric modulators (NAMs) of metabotropic glutamate receptor subtype 5 (mGlu
5 ) have potential applications in the treatment of fragile X syndrome, levodopa-induced …
5 ) have potential applications in the treatment of fragile X syndrome, levodopa-induced …
[HTML][HTML] Partial mGlu5 negative allosteric modulators attenuate cocaine-mediated behaviors and lack psychotomimetic-like effects
…, AD Thompson, HH Nickols, JP Yuh… - …, 2016 - nature.com
Cocaine abuse remains a public health concern for which pharmacotherapies are largely
ineffective. Comorbidities between cocaine abuse, depression, and anxiety support the …
ineffective. Comorbidities between cocaine abuse, depression, and anxiety support the …
Effect of Pesticides on Salicylic Acid Binding Protein 2 (SABP2) and Plant Defense
JP Yuh - 2011 - dc.etsu.edu
Tobacco SABP2 has been shown to display high affinity for salicylic acid (SA) and methylsalicylate
(MeSA) and plays an important role in SAR signal development. Using biochemical …
(MeSA) and plays an important role in SAR signal development. Using biochemical …
[PDF][PDF] VU0477573: Partial negative allosteric modulator of the subtype 5 metabotropic
HH Nickols, JP Yuh, KJ Gregory… - Journal of pharmacology … - researchgate.net
Negative allosteric modulators (NAMs) of metabotropic glutamate receptor subtype 5 (mGlu5)
have potential applications in the treatment of Fragile X syndrome, levodopa-induced …
have potential applications in the treatment of Fragile X syndrome, levodopa-induced …
A chimeric approach to purifying lentiviral vectors for CAR-T
AT McLeod, S Leung, JP Yuh, A Ghorbani, R Ramanuj… - Cytotherapy, 2019 - Elsevier
Background & Aim Lentiviral vectors (LVV) are the most common delivery method for
transducing T cells for CAR-T therapies, and their production and purification are major cost-drivers …
transducing T cells for CAR-T therapies, and their production and purification are major cost-drivers …
Outcome of adult severe or very severe aplastic anemia treated with immunosuppressive therapy compared with bone marrow transplantation: multicenter trial
…, SY Jung, HJ Yoon, KS Cho, JA Lee, YJ Yuh… - International journal of …, 2003 - Springer
To compare survival rates and long-term complications after bone marrow transplantation (BMT)
or treatment with immunosuppressive agents (ISA) in the management of adult aplastic …
or treatment with immunosuppressive agents (ISA) in the management of adult aplastic …
The status of robotics
G Bekey, J Yuh - IEEE Robotics & Automation Magazine, 2008 - ieeexplore.ieee.org
This article is the second part of a summary report on the status of robotics in the United
States, Western Europe, Korea, Japan, and Australia. This report is based on visits to over 50 …
States, Western Europe, Korea, Japan, and Australia. This report is based on visits to over 50 …
A preliminary study on the taxonomy of the family Magnoliaceae
L Yuh-Wu, L Yuh‐Wu - Journal of Systematics and Evolution, 1984 - jse.ac.cn
A new system of classification of Magnoliaceae proposed. This paper deals mainly with
taxonomy and phytogeography of the family Magnoliaceae on the basis of external morphology, …
taxonomy and phytogeography of the family Magnoliaceae on the basis of external morphology, …