The vanilloid receptor-1 (VR1) is a ligand-gated, non-selective cation channel expressed
predominantly by sensory neurons. VR1 responds to noxious stimuli including capsaicin, the …

The localization of orexin neuropeptides in the lateral hypothalamus has focused interest on
their role in ingestion. The orexigenic neurones in the lateral hypothalamus, however, …

The P2X 7 purinoceptor is a ligand-gated cation channel, expressed predominantly by cells
of immune origin, with a unique phenotype which includes release of biologically active …

ATP is a known mediator of inflammatory and neuropathic pain. However, the mechanisms
by which specific purinergic receptors contribute to chronic pain states are still poorly …

It has been postulated that the G protein-coupled receptor, GPR55, is a third cannabinoid
receptor. Given that the ligands at the CB 1 and CB 2 receptors are effective analgesic and anti-…

The P2X 7 purinoceptor is unique amongst the P2X receptor family in that its activation is
able to stimulate the release of mature, biologically active interleukin-1β (IL-1β), as well as a …

We used a mouse with deletion of exons 4, 5, and 6 of the SCN11A (sodium channel,
voltage-gated, type XI, α) gene that encodes the voltage-gated sodium channel Na v 1.9 to assess …

Often in research involving genetically modified mice, novel targets are being investigated
about which little or nothing is known. In general, pharmacological tools are not available and …

Rationale: Orexin-A and orexin-B are hypothalamic neuropeptides derived from a 130-amino
acid precursor, prepro-orexin, and are potent agonists at both the orexin-1 (OX 1 ) and …

P2X4 is a ligand-gated ion channel implicated in neuropathic pain. Drug discovery efforts
targeting P2X4 have been unsuccessful largely because of the difficulty in engineering …