Cardiovascular disease is the leading cause of death worldwide, accounting for almost a
third of deaths. 1 Although advances in research and cardiac care have increased survival, …

Purpose: Fibroblast activity promotes adverse left ventricular (LV) remodeling that underlies
the development of ischemic cardiomyopathy. Transforming growth factor-β (TGF-β) is a …

Heart failure due to severe obesity is a complex disease due to multiple mechanisms,
including increased body mass, inflammation, and impaired cardiac metabolism that is …

The ability to extract somatic cells from a patient and reprogram them to pluripotency opens
up new possibilities for personalized medicine. Induced pluripotent stem cells (iPSCs) have …

… Western blot analysis of eNOS, iNOS, PAR-1, β-actin and glyceraldehyde 3-phosphate
dehydrogenase (GAPDH) expression was carried out as previously described (Strande et al. …

X-linked myotubular myopathy (XLMTM) results from MTM1 gene mutations and myotubularin
deficiency. Most XLMTM patients develop severe muscle weakness leading to respiratory …

Obesity is a major public health crisis. Multi-specific peptides have emerged as promising
therapeutic strategies for clinical weight loss. Glucagon-like peptide-1 (GLP-1) and glucose-…

Myocardial ischemia/reperfusion (I/R) injury is partly mediated by thrombin. In support, the
functional inhibition of thrombin has been shown to decrease infarct size after I/R. Several …

The mushroom bodies, the insect brain structures most often associated with learning,
exhibit structural plasticity during adult behavioral development in honey bees. We have …

Background: Dystrophin-deficient cardiomyopathy is a growing clinical problem without
targeted treatments. We investigated whether nicorandil promotes cardioprotection in human …