The endothelial cell ecto-ADPase responsible for inhibition of platelet function is CD39.

…, MJ Broekman, JH Drosopoulos… - The Journal of …, 1997 - Am Soc Clin Investig
We previously demonstrated that when platelets are in motion and in proximity to endothelial
cells, they become unresponsive to agonists (Marcus, AJ, LB Safier, KA Hajjar, HL Ullman, …

Inhibition of platelet function by recombinant soluble ecto-ADPase/CD39.

…, K Brasel, V Price, JH Drosopoulos… - The Journal of …, 1998 - Am Soc Clin Investig
Excessive platelet accumulation and recruitment, leading to vessel occlusion at sites of
vascular injury, present major therapeutic challenges in cardiovascular medicine. Endothelial …

CD39/NTPDase-1 activity and expression in normal leukocytes

…, MJ Broekman, KE Olson, JHF Drosopoulos… - Thrombosis research, 2007 - Elsevier
INTRODUCTION: CD39/NTPDase-1 is a cell surface enzyme expressed on leukocytes and
endothelial cells that metabolizes ATP to ADP and AMP. CD39 is expressed on numerous …

Optimizing human apyrase to treat arterial thrombosis and limit reperfusion injury without increasing bleeding risk

…, MJ Broekman, A Nguyen, JHF Drosopoulos… - Science translational …, 2014 - science.org
In patients with acute myocardial infarction undergoing reperfusion therapy to restore blood
flow through blocked arteries, simultaneous inhibition of platelet P2Y 12 receptors with the …

Quercetin enhances TRAIL-mediated apoptosis in colon cancer cells by inducing the accumulation of death receptors in lipid rafts

FH Psahoulia, KG Drosopoulos, L Doubravska… - Molecular cancer …, 2007 - AACR
Cytokines such as tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) can
induce apoptosis in colon cancer cells through engagement of death receptors. Nevertheless, …

Role of extracellular ATP metabolism in regulation of platelet reactivity

…, EM Gladek, HD Robertson, JHF Drosopoulos… - Journal of Laboratory …, 2002 - Elsevier
Extracellular adenosine triphosphate (ATP) regulates platelet reactivity by way of direct
action on platelet purinergic receptors or by hydrolysis to adenosine diphosphate (ADP). …

Human solCD39 inhibits injury-induced development of neointimal hyperplasia

JHF Drosopoulos, R Kraemer, H Shen… - Thrombosis and …, 2010 - thieme-connect.com
Blood platelets provide the initial response to vascular endothelial injury, becoming
activated as they adhere to the injured site. Activated platelets recruit leukocytes, and initiate …

Enhanced fidelity of 3TC-selected mutant HIV-1 reverse transcriptase

MA Wainberg, WC Drosopoulos, H Salomon, M Hsu… - Science, 1996 - science.org
Monotherapy with (−)2′,3′-dideoxy-3′-thiacytidine (3TC) leads to the appearance of a
drug-resistant variant of human immunodeficiency virus-type 1 (HIV-1) with the methionine-…

[HTML][HTML] Heterologous cell–cell interactions: thromboregulation, cerebroprotection and cardioprotection by CD39 (NTPDase-1)

AJ Marcus, MJ Broekman, JHF Drosopoulos… - Journal of thrombosis …, 2003 - Elsevier
Blood platelets maintain vascular integrity and promote primary and secondary hemostasis
following interruption of vessel continuity. Biochemical or physical damage to the coronary, …

Human telomeres replicate using chromosome-specific, rather than universal, replication programs

WC Drosopoulos, ST Kosiyatrakul, Z Yan… - Journal of Cell …, 2012 - rupress.org
Telomeric and adjacent subtelomeric heterochromatin pose significant challenges to the
DNA replication machinery. Little is known about how replication progresses through these …