User profiles for J. F. Disterhoft

John F Disterhoft

Professor, Northwestern University
Verified email at northwestern.edu
Cited by 24319

Learning, aging and intrinsic neuronal plasticity

JF Disterhoft, MM Oh - Trends in neurosciences, 2006 - cell.com
In vitro experiments indicate that intrinsic neuronal excitability, as evidenced by changes in
the post-burst afterhyperpolarization (AHP) and spike-frequency accommodation, is altered …

Where is the trace in trace conditioning?

DS Woodruff-Pak, JF Disterhoft - Trends in neurosciences, 2008 - cell.com
Intensive mapping of the essential cerebellar brain circuits for Pavlovian eyeblink conditioning
appeared relatively complete by 2000, but new data indicate the need for additional …

Calcium-dependent afterhyperpolarization and learning in young and aging hippocampus

JF Disterhoft, LT Thompson, JR Moyer Jr, DJ Mogul - Life sciences, 1996 - Elsevier
Hippocampally-dependent trace eyeblink conditioning has been shown to be affected by
aging. Aging animals take more trials to acquire the association and are more likely to be …

Hippocampectomy disrupts trace eye-blink conditioning in rabbits.

JR Moyer, RA Deyo, JF Disterhoft - 2015 - psycnet.apa.org
… Correspondence concerning this article should be addressed to John F. Disterhoft, Department
of Cell, Molecular, and Structural Biology, Northwestern University Medical School, 303 …

[PDF][PDF] BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease

…, SG Younkin, M Citron, R Vassar, JF Disterhoft - Neuron, 2004 - cell.com
β-site APP cleaving enzyme 1 (BACE1) is the β-secretase enzyme required for generating
pathogenic β-amyloid (Aβ) peptides in Alzheimer's disease (AD). BACE1 knockout mice lack …

Hippocampectomy disrupts auditory trace fear conditioning and contextual fear conditioning in the rat

…, W Tseng, C Weiss, JF Disterhoft - …, 1998 - Wiley Online Library
The hippocampus is believed to be an important structure for learning tasks that require
temporal processing of information. The trace classical conditioning paradigm requires temporal …

Trace eyeblink conditioning increases CA1 excitability in a transient and learning-specific manner

…, LT Thompson, JF Disterhoft - Journal of …, 1996 - Soc Neuroscience
Time-dependent, learning-related changes in hippocampal excitability were evaluated by
recording from rabbit CA1 pyramidal neurons in slices prepared at various times after …

Balanced gene regulation by an embryonic brain ncRNA is critical for adult hippocampal GABA circuitry

…, EA Sametsky, MF Clark, JC Savage, JF Disterhoft… - Nature …, 2009 - nature.com
Genomic studies demonstrate that, although the majority of the mammalian genome is
transcribed, only about 2% of these transcripts are code for proteins. We investigated how the long…

BACE1 gene deletion prevents neuron loss and memory deficits in 5XFAD APP/PS1 transgenic mice

…, J Zhao, M Citron, R Berry, JF Disterhoft… - Neurobiology of …, 2007 - Elsevier
Evidence suggests that β-amyloid (Aβ) peptide triggers a pathogenic cascade leading to
neuronal loss in Alzheimer’s disease (AD). However, the causal link between Aβ and neuron …

Nimodipine increases excitability of rabbit CA1 pyramidal neurons in an age-and concentration-dependent manner

…, JP Black, JF Disterhoft - Journal of …, 1992 - journals.physiology.org
1. Cellular properties were studied before and after bath application of the dihydropyridine L-type
calcium channel antagonist nimodipine in aging and young rabbit hippocampal CA1 …