Postoperative cognitive dysfunction, confusion, and delirium are common after general
anesthesia in the elderly, with symptoms persisting for months or years in some patients. Even …

CRISPR-Cas RNA-guided endonucleases hold great promise for disrupting or correcting
genomic sequences through site-specific DNA cleavage and repair. However, the lack of …

LY-450139 is a γ-secretase inhibitor shown to have efficacy in multiple cellular and animal
models. Paradoxically, robust elevations of plasma amyloid-β (Aβ) have been reported in …

A compact and stable bicyclic bridged ketal was developed as a ligand for the asialoglycoprotein
receptor (ASGPR). This compound showed excellent ligand efficiency, and the …

PF-3084014 [(S)-2-((S)-5,7-difluoro-1,2,3,4-tetrahydronaphthalen-3-ylamino)-N-(1-(2-methyl-1-(neopentylamino)propan-2-yl)-1H-imidazol-4-yl)pentanamide]
is a novel γ-secretase …

Microphysiological systems (MPS) are making advances to provide more standardized and
predictive physiologically relevant responses to test articles in living tissues and organ …

A novel series of tetralin containing amino imidazoles, derived from modification of the
corresponding phenyl acetic acid derivatives is described. Replacement of the amide led to …

Striatal‐enriched protein tyrosine phosphatase (STEP) has been described as a regulator of
multiple kinases and glutamate receptor subunits critical for synaptic plasticity. Published …

The synthesis and structure–activity relationship (SAR) of a novel series of di-substituted
imidazoles, derived from modification of DAPT, are described. Subsequent optimization led to …

Alveolar type II (ATII) epithelial cells contain lamellar bodies (LBs) which synthesize and
store lung surfactants. In animals, the inhibition or knockout of leucine-rich repeat kinase 2 (…