The leptin hormone is critical for normal food intake and metabolism. While leptin receptor (Lepr)
function has been well studied in the hypothalamus, the functional relevance of Lepr …

Conditional mutant techniques that allow spatial and temporal control over gene expression
can be used to create mice with restricted genetic modifications. These mice serve as …

Melanin-concentrating hormone (MCH) is a hypothalamic neuropeptide with a prominent
role in feeding and energy homeostasis. The rodent MCH receptor (MCH1R) is highly …

The prototypic second messenger cyclic AMP (cAMP) is essential for controlling cellular
metabolism, including glucose and lipid homeostasis. In mammals, the majority of cAMP …

There is a critical need for new mechanism-of-action drugs that reduce the burden of obesity
and associated chronic metabolic comorbidities. A potentially novel target to treat obesity …

Nicotinamide N-methyltransferase (NNMT) is a fundamental cytosolic biotransforming enzyme
that catalyzes the N-methylation of endogenous and exogenous xenobiotics. We have …

Psychiatric disorders such as anxiety, depression and addiction are often comorbid brain
pathologies thought to share common mechanistic biology. As part of the cortico-limbic circuit, …

Neuromedin U (NMU) is a highly conserved neuropeptide which regulates food intake and
body weight. Transgenic mice lacking NMU are hyperphagic and obese, making NMU a …

Resilience and vulnerability to neuropsychiatric disorders are linked to molecular changes
underlying excitability that are still poorly understood. Here, we identify glycogen-synthase …

There is growing evidence that over consumption of high-fat foods and insulin resistance
may alter hippocampal-dependent cognitive function. To study the individual contributions of …