Endoplasmic reticulum (ER) is a multifaceted organelle that regulates protein synthesis and
trafficking, cellular responses to stress, and intracellular Ca 2+ levels. In neurons, it is …

Let’s first set the record straight. Caffeine is a drug. In fact, it is the most widely ingested
psychoactive drug in the world. That’s rightmore than alcohol, more than marijuana, more than …

Sporadic Alzheimer's disease (AD) and Parkinson's disease (PD) are two of the most common
neurodegenerative diseases and as such they represent major public health problems. …

Objective The full anticonvulsant effect of the ketogenic diet (KD) can require weeks to develop
in rats, suggesting that altered gene expression is involved. The KD typically is used in …

Creatine, one of the most common food supplements used by individuals at almost every
level of athleticism, promote gains in performance, strength, and fat‐free mass. Recent …

Dendritic cells (DCs) have been shown to be a promising adjuvant for inducing immunity to
cancer. We evaluated tumor lysate-pulsed DC in a Phase I trial of pediatric patients with solid …

Many cases of early-onset inherited Alzheimer's disease (AD) are caused by mutations in
the presenilin-1 (PS1) gene. PS1 mutations may perturb cellular Ca 2+ homeostasis and …

Sleep is thought to be restorative in function, but what is restored during sleep is unclear.
Here we tested the hypothesis that increased periods of wakefulness will result in decreased …

Tat is an 86- to 104-amino-acid viral protein that activates human immunodeficiency virus
type 1 expression, modifies several cellular functions, and causes neurotoxicity. Here, we …

Dendritic cells (DCs) are antigen-presenting cells that play a major role in initiating primary
immune responses. We have utilized two independent approaches, DNA microarrays and …