Population pharmacokinetic studies in pediatrics: issues in design and analysis
B Meibohm, S Läer, JC Panetta, JS Barrett - The AAPS journal, 2005 - Springer
The current review addresses the following 3 frequently encountered challenges in the
design and analysis of population pharmacokinetic studies in pediatrics: (1) body size …
design and analysis of population pharmacokinetic studies in pediatrics: (1) body size …
Modeling immunotherapy of the tumor–immune interaction
D Kirschner, JC Panetta - Journal of mathematical biology, 1998 - Springer
A number of lines of evidence suggest that immunotherapy with the cytokine interleukin-2 (IL-2)
may boost the immune system to fight tumors. CD4 + T cells, the cells that orchestrate the …
may boost the immune system to fight tumors. CD4 + T cells, the cells that orchestrate the …
Mrp4 confers resistance to topotecan and protects the brain from chemotherapy
…, G Du, KE Mercer, Y Zhuang, JC Panetta… - … and cellular biology, 2004 - Taylor & Francis
The role of the multidrug resistance protein MRP4/ABCC4 in vivo remains undefined. To
explore this role, we generated Mrp4-deficient mice. Unexpectedly, these mice showed …
explore this role, we generated Mrp4-deficient mice. Unexpectedly, these mice showed …
[HTML][HTML] Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects
…, N Shimasaki, W Yang, JC Panetta… - Journal of Clinical …, 2009 - ncbi.nlm.nih.gov
… Panetta, Cheng Cheng, Deqing Pei, Diana Chan, Alex Sparreboom, Kathleen M.
Giacomini, William E. Evans, Mary V. … Pauley JL, Panetta JC, Schmidt J, et al. Late-onset …
Giacomini, William E. Evans, Mary V. … Pauley JL, Panetta JC, Schmidt J, et al. Late-onset …
[HTML][HTML] Methotrexate-induced neurotoxicity and leukoencephalopathy in childhood acute lymphoblastic leukemia
…, D Pei, JJ Yang, RB Khan, JC Panetta… - Journal of clinical …, 2014 - ncbi.nlm.nih.gov
Purpose Methotrexate (MTX) can cause significant clinical neurotoxicity and asymptomatic
leukoencephalopathy. We sought to identify clinical, pharmacokinetic, and genetic risk factors …
leukoencephalopathy. We sought to identify clinical, pharmacokinetic, and genetic risk factors …
Pharmacokinetic, pharmacodynamic, and pharmacogenetic determinants of osteonecrosis in children with acute lymphoblastic leukemia
…, SC Kaste, D Pei, JC Panetta… - Blood, The Journal …, 2011 - ashpublications.org
Osteonecrosis is a severe glucocorticoid-induced complication of acute lymphoblastic
leukemia treatment. We prospectively screened children (n = 364) with magnetic resonance …
leukemia treatment. We prospectively screened children (n = 364) with magnetic resonance …
A mathematical model of periodically pulsed chemotherapy: tumor recurrence and metastasis in a competitive environment
JC Panetta - Bulletin of mathematical Biology, 1996 - Springer
A competition model describing tumor-normal cell interaction with the added effects of
periodically pulsed chemotherapy is discussed. The model describes parameter conditions …
periodically pulsed chemotherapy is discussed. The model describes parameter conditions …
[HTML][HTML] Molecular biology of breast metastasis The use of mathematical models to determine relapse and to predict response to chemotherapy in breast cancer
SE Clare, F Nakhlis, JC Panetta - Breast Cancer Research, 2000 - Springer
… In a similar manner, Panetta [37] defined a model that describes a heterogeneous tumor
population and the effects of chemotherapy. The model is used to determine conditions on …
population and the effects of chemotherapy. The model is used to determine conditions on …
Genome-wide study of methotrexate clearance replicates SLCO1B1
LB Ramsey, JC Panetta, C Smith… - Blood, The Journal …, 2013 - ashpublications.org
Methotrexate clearance can influence the cure of and toxicity in children with acute lymphoblastic
leukemia (ALL). We estimated methotrexate plasma clearance for 1279 patients with …
leukemia (ALL). We estimated methotrexate plasma clearance for 1279 patients with …
Optimal control applied to cell-cycle-specific cancer chemotherapy
JC Panetta, KR Fister - SIAM Journal on Applied Mathematics, 2000 - SIAM
… In a different approach, Panetta [14] and Panetta and Higgins [15] use deterministic systems
of ordinary differential equations, which include both the active and resting phases of the cell…
of ordinary differential equations, which include both the active and resting phases of the cell…