Population pharmacokinetic studies in pediatrics: issues in design and analysis

B Meibohm, S Läer, JC Panetta, JS Barrett - The AAPS journal, 2005 - Springer
The current review addresses the following 3 frequently encountered challenges in the
design and analysis of population pharmacokinetic studies in pediatrics: (1) body size …

Modeling immunotherapy of the tumor–immune interaction

D Kirschner, JC Panetta - Journal of mathematical biology, 1998 - Springer
A number of lines of evidence suggest that immunotherapy with the cytokine interleukin-2 (IL-2)
may boost the immune system to fight tumors. CD4 + T cells, the cells that orchestrate the …

Mrp4 confers resistance to topotecan and protects the brain from chemotherapy

…, G Du, KE Mercer, Y Zhuang, JC Panetta… - … and cellular biology, 2004 - Taylor & Francis
The role of the multidrug resistance protein MRP4/ABCC4 in vivo remains undefined. To
explore this role, we generated Mrp4-deficient mice. Unexpectedly, these mice showed …

[HTML][HTML] Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects

…, N Shimasaki, W Yang, JC Panetta… - Journal of Clinical …, 2009 - ncbi.nlm.nih.gov
Panetta, Cheng Cheng, Deqing Pei, Diana Chan, Alex Sparreboom, Kathleen M.
Giacomini, William E. Evans, Mary V. … Pauley JL, Panetta JC, Schmidt J, et al. Late-onset …

[HTML][HTML] Methotrexate-induced neurotoxicity and leukoencephalopathy in childhood acute lymphoblastic leukemia

…, D Pei, JJ Yang, RB Khan, JC Panetta… - Journal of clinical …, 2014 - ncbi.nlm.nih.gov
Purpose Methotrexate (MTX) can cause significant clinical neurotoxicity and asymptomatic
leukoencephalopathy. We sought to identify clinical, pharmacokinetic, and genetic risk factors …

Pharmacokinetic, pharmacodynamic, and pharmacogenetic determinants of osteonecrosis in children with acute lymphoblastic leukemia

…, SC Kaste, D Pei, JC Panetta… - Blood, The Journal …, 2011 - ashpublications.org
Osteonecrosis is a severe glucocorticoid-induced complication of acute lymphoblastic
leukemia treatment. We prospectively screened children (n = 364) with magnetic resonance …

A mathematical model of periodically pulsed chemotherapy: tumor recurrence and metastasis in a competitive environment

JC Panetta - Bulletin of mathematical Biology, 1996 - Springer
A competition model describing tumor-normal cell interaction with the added effects of
periodically pulsed chemotherapy is discussed. The model describes parameter conditions …

[HTML][HTML] Molecular biology of breast metastasis The use of mathematical models to determine relapse and to predict response to chemotherapy in breast cancer

SE Clare, F Nakhlis, JC Panetta - Breast Cancer Research, 2000 - Springer
… In a similar manner, Panetta [37] defined a model that describes a heterogeneous tumor
population and the effects of chemotherapy. The model is used to determine conditions on …

Genome-wide study of methotrexate clearance replicates SLCO1B1

LB Ramsey, JC Panetta, C Smith… - Blood, The Journal …, 2013 - ashpublications.org
Methotrexate clearance can influence the cure of and toxicity in children with acute lymphoblastic
leukemia (ALL). We estimated methotrexate plasma clearance for 1279 patients with …

Optimal control applied to cell-cycle-specific cancer chemotherapy

JC Panetta, KR Fister - SIAM Journal on Applied Mathematics, 2000 - SIAM
… In a different approach, Panetta [14] and Panetta and Higgins [15] use deterministic systems
of ordinary differential equations, which include both the active and resting phases of the cell…