Relationship of microglial and astrocytic activation to disease onset and progression in a transgenic model of familial ALS
Transgenic mice that highly over‐express a mutated human CuZn superoxide dismutase (SOD1)
gene [gly 93 →ala; TgN(SOD1‐G93A)G1H line] found in some patients with familial …
gene [gly 93 →ala; TgN(SOD1‐G93A)G1H line] found in some patients with familial …
Treatment of mice with methamphetamine produces cell loss in the substantia nigra
PK Sonsalla, ND Jochnowitz, GD Zeevalk, JA Oostveen… - Brain research, 1996 - Elsevier
Studies were conducted to determine if treatment of mice with methamphetamine (METH)
would produce a loss of dopaminergic cells in the substantia nigra. The number of TH + /Nissl-…
would produce a loss of dopaminergic cells in the substantia nigra. The number of TH + /Nissl-…
Relationship of oxygen radical‐induced lipid peroxidative damage to disease onset and progression in a transgenic model of familial ALS
ED Hall, PK Andrus, JA Oostveen… - Journal of …, 1998 - Wiley Online Library
Transgenic mice that overexpress a mutated human CuZn superoxide dismutase (SOD1)
gene (gly 93 →ala) found in some patients with familial ALS (FALS) have been shown to …
gene (gly 93 →ala) found in some patients with familial ALS (FALS) have been shown to …
Increased amyloid protein precursor and apolipoprotein E immunoreactivity in the selectively vulnerable hippocampus following transient forebrain ischemia in gerbils
ED Hall, JA Oostveen, E Dunn, DB Carter - Experimental neurology, 1995 - Elsevier
The postischemic time course of amyloid protein precursor (APP), β-amyloid protein (β-AP),
and apolipoprotein E (APO-E) immunoreactivity were examined in comparison to neuronal …
and apolipoprotein E (APO-E) immunoreactivity were examined in comparison to neuronal …
Neuroprotective effects of the dopamine D2/D3 agonist pramipexole against postischemic or methamphetamine-induced degeneration of nigrostriatal neurons
ED Hall, PK Andrus, JA Oostveen, JS Althaus… - Brain research, 1996 - Elsevier
We have examined the neuroprotective efficacy of the selective dopamine (DA) D 2 /D 3
receptor agonist pramipexole in two models of nigrostriatal (NS) degeneration. The first involves …
receptor agonist pramipexole in two models of nigrostriatal (NS) degeneration. The first involves …
Development of a prolonged eosinophil-rich inflammatory leukocyte infiltration in the guinea-pig asthmatic response to ovalbumin inhalation
CJ Dunn, GA Elliott, JA Oostveen, IM Richards - Am Rev Respir Dis, 1988 - atsjournals.org
S~ MMARY Considerable attention has recently focused on the role of inflammation in the
pathophysiology of asthma, with special emphasis on" late-phase" bronchoconstriction and …
pathophysiology of asthma, with special emphasis on" late-phase" bronchoconstriction and …
Human apolipoprotein E4 accelerates β‐amyloid deposition in APPsw transgenic mouse brain
…, JA Oostveen, RJ Weaver, JA Boller… - Annals of Neurology …, 2001 - Wiley Online Library
The human apolipoprotein E4 (ApoE4) isoform is associated with genetic risk for Alzheimer's
disease. To assess the effects of different ApoE isoforms on amyloid plaque formation, …
disease. To assess the effects of different ApoE isoforms on amyloid plaque formation, …
[BOOK][B] Neuroprotective efficacy of microvascularly-localized versus brain-penetrating antioxidants
ED Hall, PK Andrus, SL Smith, JA Oostveen… - 1996 - Springer
The 21-aminosteroid (lazaroid) tirilazad mesylate has been demonstrated to be a potent
inhibitor of lipid peroxidation and to reduce traumatic and ischemic damage in a number of …
inhibitor of lipid peroxidation and to reduce traumatic and ischemic damage in a number of …
Neuroprotective effects of the dopamine agonists pramipexole and bromocriptine in 3-acetylpyridine-treated rats
VH Sethy, H Wu, JA Oostveen, ED Hall - Brain research, 1997 - Elsevier
The neuroprotective effects of pramipexole, a dopamine agonist, were investigated in 3-acetylpyridine
(3-AP)-treated Wistar rats. Bromocriptine was used as a reference compound to …
(3-AP)-treated Wistar rats. Bromocriptine was used as a reference compound to …
Neuroprotective efficacy and mechanisms of novel pyrrolopyrimidine lipid peroxidation inhibitors in the gerbil forebrain ischemia model
JA Oostveen, E Dunn, DB Carter… - Journal of Cerebral …, 1998 - journals.sagepub.com
A brief period of bilateral carotid occlusion (BCO)-induced forebrain ischemia in gerbils
triggers neuronal degeneration and the subsequent expression of amyloid precursor protein (…
triggers neuronal degeneration and the subsequent expression of amyloid precursor protein (…